Methotrexate vs. Aminopterin for Psoriasis

Relative risk of and determinants for adverse events of methotrexate prescribed at a low dose: a systematic review and meta-analysis of randomized placebo-controlled trials

“…Methotrexate, an old antimetabolite drug formerly called amethopterin, has been used in oncology since the late 1940s. A few years later, methotrexate was being used in dermatology and rheumatology . Since that time, its efficacy when prescribed at immunomodulatory doses (i.e.…”

Clinical Clearing of Psoriasis by 6-Thioguanine Correlates With Cutaneous T-Cell Depletion via Apoptosis

“…Improvement of psoriasis was then observed with other antimetabolites, including amethopterin, 5-fluorouracil, actinomycin D, and 6-mercaptopurine. [2][3][4] In 1964, Demis et al 5 reported prompt remission in 2 chronic cases after a 2-week course of 6-thioguanine. The mechanism of action of these agents in psoriasis, however, was unclear.…”

Radioactive Iron Studies in Patients Treated with Methotrexate for Psoriasis

“…Much work has since been done by Rees [7], Doles [4] and Strakosh [9], using Aminopterin and M ethotrexate singly or interchangeably with different dosage sched ules, in an effort to obtain the most benefit and the least complications and to obviate the emergence of resistance. More recently, Van Scott [8J and Auerbach [1] used M ethotrexate parenterally, to induce remissions and as m aintenance therapy in patients with psoriasis.…”