Methotrexate Causes Oxidative Stress in Rat Kidney Tissues

Devrım, Erdinç; Çetin, Recep; Kilicoglu, Bulent; Ergüder, Berrin İmge; Avcı, Aslıhan; Durak, İlker

doi:10.1080/08860220500244823

Cited by 59 publications

(39 citation statements)

References 20 publications

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“…The pathogenesis of Mtx nephrotoxicity involves multiple pathways, including oxidative stress and inflammation (Devrim et al, 2005;Asvadi et al, 2011). Inflammatory mediators including TNF-α, IL-1 and NO, known as endothelium-derived relaxing factor (EDRF) are shown to play important roles in the pathogenesis of Mtx nephrotoxicity (Ibrahim et al, 2014;Kirbas et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Oğuz

Koçarslan²,

Tabur³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Methotrexate (Mtx), used for its anticancer and immunsuppresive properties, is known to be a nephrotoxic agent. We aimed to investigate the effects of lycopene (Lyc) alone or combined with melatonin (Mel) on Mtxinduced nephrotoxicity since both of these agents have antioxidant and anti-inflammatory effects. Nephrotoxicity was induced by intraperitoneal administration of methotrexate at a dose of 20 mg/kg. Treatment both with Lyc alone and Lyc combined with Mel provided significant reduction in tumor necrosis factor-alpha, interleukin 1-beta and ceruloplasmin levels in Mtx administered rats. Hovewer, Lyc combined with Mel provided a significant reduction also in NO levels. Hstopathological examination showed that there was an obvious improvement in the degenerative changes compared to Mtx administrated group with the Lyc combined Mel group giving best protection. In conclusion Lyc alone and combined with Mel provided significant improvement against renal damage caused by Mtx, preseumably via antioxidant and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 99%

“…It has been suggested that oxidative stress and inflammation may have role inthe pathogenesis of MTX-induced nephrotoxicity rather than blockage in folate synthesis in kidneys (Devrim et al, 2005;Asvadi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Oğuz

Koçarslan²,

Tabur³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…The results of biochemical tests showed a significant increase in the liver tissue of the MTXC group in the levels of oxidant parameters, e.g., MDA and MPO, and a decrease in anti-oxidant parameters, e.g., GSH and SOD. Oxidative stress is implicated in methotrexate toxicity in the liver 11 . Oxidative stress is an indicator of the damage that results from a change in the balance between oxidants and anti-oxidants in favour of oxidants.…”

Section: Discussionmentioning

confidence: 99%

The effect of mirtazapine on methotrexate-induced toxicity in rat liver

Özoğul¹,

Kısaoğlu²,

Turan³

et al. 2013

ScienceAsia

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Methotrexate is used as a chemotherapeutic agent and its anti-oxidant activity is used to treat many cancer types. This study conducts a biochemical and histopathological investigation into whether mirtazapine has a protective effect on methotrexate-induced hepatotoxicity in rats. Distilled water was given to a healthy group intraperitoneally. Methotrexate alone was injected in the control group, again intraperitoneally. Mirtazapine and, 1 h later, methotrexate were given to the rats in the final group. This procedure was repeated over 7 days. In the control group rats receiving methotrexate, blood AST, ALT, and LDH levels were 227 ± 3 µmol/l, 85 ± 2 µmol/l, and 357 ± 13 µmol/l, respectively. In the rats receiving mirtazapine and methotrexate, these values were 152 ± 3 µmol/l, 25 ± 1 µmol/l, and 141 ± 15 µmol/l. In the healthy rat group, AST, ALT, and LDH levels were 136 µmol/l, 20 µmol/l, and 133 µmol/l, respectively. Histopathologically, apoptotic bodies with condensed cytoplasm, peripheral, and pyknotic nuclei in the hepatocytes, focal necrosis and intense inflammation in the interstitial areas were present in the control group. In the methotrexate and mirtazapine group, there were no apoptotic bodies or inflammation, only isolated necrosis in the hepatocytes. In conclusion, mirtazapine protected the liver against methotrexate toxicity.

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“…Our results were parallel to some studies which indicated, the after MTX intoxication, significant depletion of the GSH level and also significant decreases in activities of SOD, CAT and GPx was evidenced, corroborating the state of oxidative stress. 23,32,33 MDA is one of the most commonly markers of lipid peroxidation. Lipid peroxidation is a wellknown mechanism of cellular injury in the human body.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effects of Hydroalcoholic Extract of Lavandula officinalis L. on Methotrexate-Induced Oxidative Stress in Rats

Kalantar¹,

Shirali²,

Hasanvand³

et al. 2017

Pharm Sci

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Methotrexate Causes Oxidative Stress in Rat Kidney Tissues

Abstract: It has been suggested that MTX leads to oxidative stress in rat kidney tissues, which might be one of the reasons for MTX-induced nephrotoxicity.

Cited by 59 publications

References 20 publications

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

The effect of mirtazapine on methotrexate-induced toxicity in rat liver

Ameliorative Effects of Hydroalcoholic Extract of Lavandula officinalis L. on Methotrexate-Induced Oxidative Stress in Rats

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