1984
DOI: 10.1001/archderm.120.2.155a
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Methotrexate and etretinate as concurrent therapies in the treatment of psoriasis

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“…41 Although this combination can be very effective, sporadic severe hepatotoxic responses have been reported. [42][43][44] The efficacy of concomitant use of acitretin with ciclosporin is not convincing 45 and, in addition, this combination carries the risk of accumulation of ciclosporin as both drugs are inactivated by the same cytochrome P-450 system.…”
Section: Other Combinationsmentioning
confidence: 99%
“…41 Although this combination can be very effective, sporadic severe hepatotoxic responses have been reported. [42][43][44] The efficacy of concomitant use of acitretin with ciclosporin is not convincing 45 and, in addition, this combination carries the risk of accumulation of ciclosporin as both drugs are inactivated by the same cytochrome P-450 system.…”
Section: Other Combinationsmentioning
confidence: 99%