Methods for the determination of seven selective serotonin reuptake inhibitors and three active metabolites in human serum using high-performance liquid chromatography and gas chromatography

Lacassie, Éric; Gaulier, Jean‐Michel; Marquet, Pierre; Rabatel, Julien; Lachâtre, Gérard

doi:10.1016/s0378-4347(00)00159-6

Cited by 127 publications

(73 citation statements)

References 20 publications

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“…It is naphthalene amine-derivative that differs structurally from classic tricyclic antidepressants and has minimal side effects. 27 Sertraline and other new antidepressants have been analyzed in biological materials using HPLC, 28 tandem mass spectrometry, 29 gas chromatography 30 and flame ionization mass spectrometry. 31 Some of them have either a very high limit of quantification (LOQ) or are too much complex, which limits its application for a larger number of samples.…”

Section: Introductionmentioning

confidence: 99%

Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids

Arvand¹,

Hashemi²

2012

J. Braz. Chem. Soc.

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Um quimiossensor potenciométrico para determinação seletiva de sertralina foi desenvolvido, baseado na técnica de impressão molecular. O polímero impresso molecularmente foi sintetizado através da polimerização por precipitação, usando hidrocloreto de sertralina como molécula molde, ácido metacrílico como monômero funcional e dimetacrilato de etileno glicol como um agente de ligação cruzada. O sensor foi desenvolvido pela dispersão das partículas de polímero impressas na sertralina, em plastificante dibutil sebacato e incorporação em matiz de poli(cloreto de vinila). As características do sensor proposto foram avaliadas medindo a resposta do potencial para hidrocloreto de sertralina, no intervalo de 1,0 µmol L -1 a 10 mmol L -1 com resposta Nernstiniana de 57,7 mV década -1 e um limite de detecção de 0,8 µmol L -1 . Os coeficientes de seletividade potenciométrica do sensor proposto foram avaliados e exibiram boa seletividade para sertralina com relação a outros antidepressivos. Foi usado como eletrodo indicador na determinação potenciométrica de sertralina em comprimidos e fluidos biológicos.A potentiometric chemosensor for selective determination of sertraline was developed based on the molecular imprinting technique. The molecularly imprinted polymer was synthesized by precipitation polymerization, using sertraline hydrochloride as a template molecule, methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. The sensor was developed by dispersing the sertraline imprinted polymer particles in dibutyl sebacate plasticizer and embedding in poly(vinyl chloride) matrix. Characteristics of the proposed sensor were evaluated by measuring the potential response to sertraline hydrochloride in the range from 1.0 µmol L -1 to 10 mmol L -1 with a near Nernstian response of 57.7 mV decade -1 and a limit of detection of 0.8 µmol L -1 . The potentiometric selectivity coefficients of the proposed sensor were evaluated and it exhibited good selectivity to sertraline with respect to the other antidepressants. It was used as indicator electrode in potentiometric determination of sertraline in tablets and biological fluids.

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Section: Introductionmentioning

confidence: 99%

Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids

Arvand¹,

Hashemi²

2012

J. Braz. Chem. Soc.

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“…The determination of STR in serum and plasma is generally performed by high performance liquid chromatography (HPLC) coupled with spectrophotometric detectors, ultraviolet/diode array [1][2][3][4][5][6] and fluorimetric [7,8]. The wide spread usage of HPLC methods is justified by the high sensitivity and low limit of detection usually obtained and the possibility of the simultaneous analysis of the drug and its metabolites, which increases its usage even further.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical study of the antidepressant sertraline

Nouws

Delerue–Matos

Barros

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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A flow injection square wave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20 × 10 −6 and 1.20 × 10 −6 mol L −1 . Limits of detection and quantification were found to be 1.5 × 10 −7 and 5.0 × 10 −7 mol L −1 , respectively. Up to 70 samples per hour can be analysed with a good precision (R.S.D. = 2.5%). The proposed method was successfully applied to the determination of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs, opening the possibility to compete with the chromatographic methods generally used for this analysis.

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“…Ainsi, en CLHP on observe entre pH 3 et pH 5 un changement de l'état d'ionisation de la mirtazapine à l'origine d'une variation importante de son tR. La majorité des études décrites dans la littérature pour le dosage des nouveaux antidépresseurs est réalisée à un pH acide en général proche de pH 4 (9,20). Dans ces conditions, il est donc important de préparer les phases mobiles dans des conditions parfaitement définies, permettant d'obtenir un pH précis.…”

Section: Resultsunclassified

Étude du comportement analytique de la mirtazapine en chromatographie liquide haute performance et électrophorèse capillaire de zone

et al. 2001

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Methods for the determination of seven selective serotonin reuptake inhibitors and three active metabolites in human serum using high-performance liquid chromatography and gas chromatography

Cited by 127 publications

References 20 publications

Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids

Synthesis by precipitation polymerization of a molecularly imprinted polymer membrane for the potentiometric determination of sertraline in tablets and biological fluids

Electroanalytical study of the antidepressant sertraline

Étude du comportement analytique de la mirtazapine en chromatographie liquide haute performance et électrophorèse capillaire de zone

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