Methodologies for assessment of limit of detection and limit of identification using surface-enhanced Raman spectroscopy

Massarini, Enrico; Wästerby, Pär; Landström, Lars; Lejon, Christian; Beck, Olof; Andersson, Per Ola

doi:10.1016/j.snb.2014.09.116

Cited by 74 publications

(60 citation statements)

References 42 publications

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“…These response curves had profiles typical for this class of experiment. 58,60 The Raman spectral intensity at a given analyte concentration was strongly dependent upon the support material and preparation, with a substantial penalty in signal strength imposed by the excitation power limitations required by the cellulose substrates. Following low signal intensities in the test measurement for replated Silmeco substrates in Figure 2, we pursued structural characterization (vide infra)-instead of further spectral characterization-in an effort to understand this lower response compared to as-supplied Silmeco substrates.…”

mentioning

confidence: 99%

General Strategy To Make an On-Demand Library of Structurally and Functionally Diverse SERS Substrates

Karawdeniya

Bandara

Whelan

et al. 2018

ACS Appl. Nano Mater.

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Surface enhanced Raman spectroscopy; SERS; electroless plating; metallization.ABSTRACT Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for sensing molecules proximal to suitable coinage metal surfaces. The physical structure of the SERS-active metal layer and its support is a key design parameter inspiring considerable, and frequently specialized, efforts in substrate fabrication. The necessary gold film structure can arise from both the metallization process and the underlying support structure, and the structure of the support can deliver additional functions including analytical capabilities such as physical filtering. We used electroless plating as a general approach to create a library of SERS substrates: SERSactive gold films on a range of supports made from a variety of materials, made with a mixture of simple and complex fabrication histories, and offering a selection of structurally-derived functions. The result was that supports with existing functions had their capabilities enhanced by the addition of SERS sensing. Electroless plating thus offers a host of beneficial characteristics 3 for nanofabricating multifunctional SERS substrates, including: tolerance to substrate composition and form factor; low equipment overhead requirements; process chemistry flexibility-including compatibility with conventional top-down nanofabrication; and a lengthy history of commercial application as a simple metallization technique. We gold-plated standard nanofabrication-compatible silicon nitride support surfaces with planar and porous architectures, and with native and polymer-grafted surface chemistries. We used the same plating chemistry to form SERS-active gold films on cellulose fibers arrayed in commercial filter paper and formed into nanocellulose paper. In a functional sense, we used electroless plating to augment nanoporous filters, chromatography platforms, and nanofabrication building blocks with SERS capability.

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mentioning

confidence: 99%

General Strategy To Make an On-Demand Library of Structurally and Functionally Diverse SERS Substrates

Karawdeniya

Bandara

Whelan

et al. 2018

ACS Appl. Nano Mater.

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“…A detection limit as low as 9 ng of heroin and 15 ng of cocaine was achieved. Most recently, Massarini et al . systematically evaluated commercial SERS substrates in terms of limit of detection, limit of identification and dynamic range for common narcotic drug analytes, including cocaine, amphetamine and morphine.…”

Section: Raman Spectroscopy In Forensic Toxicologymentioning

confidence: 99%

Raman spectroscopy in forensic analysis: identification of cocaine and other illegal drugs of abuse

Penido

Pacheco

Lednev

et al. 2016

J Raman Spectroscopy

149

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*Current forensic methods for detecting and identifying cocaine and other drugs of abuse are destructive, so evidence cannot be re-analyzed. Raman spectroscopy, based on inelastic light scattering, allows for rapid, inexpensive and nondestructive analysis in forensic science. This review presents the state-of-the-art use of Raman spectroscopy as a confirmatory method for the identification of cocaine and other drugs of abuse in seized samples, including hidden compounds in legal materials such as beverages and clothes, among others, used for trafficking. Quantitative Raman spectroscopy is used to determine the actual drug concentrations in street cocaine and crack rocks and to identify possible adulterants in these samples for forensic toxicology and criminalistics. Finally, recent developments in Raman spectrometers (portable instruments and new excitation wavelengths) and advancements in data analysis offer exciting opportunities for new applications of Raman spectroscopy in the identification and quantification of drugs of abuse, including investigations conducted immediately at the scene of a crime.

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“…Please do not adjust margins Regarding limits of detection (LoD), different approaches have been considered, 45,46 although all of them were of limited applicability here. Indeed, in this study OBD-LDPE constituted at the same time the matrix, the analyte itself and the substrate for silver nanoparticles deposition.…”

Section: Please Do Not Adjust Marginsmentioning

confidence: 99%

Fast assessment of oxo-biodegradable polyethylene film oxidation by surface-enhanced Raman scattering with in situ formation of a silver nanoparticle substrate

2017

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Methodologies for assessment of limit of detection and limit of identification using surface-enhanced Raman spectroscopy

Cited by 74 publications

References 42 publications

General Strategy To Make an On-Demand Library of Structurally and Functionally Diverse SERS Substrates

General Strategy To Make an On-Demand Library of Structurally and Functionally Diverse SERS Substrates

Raman spectroscopy in forensic analysis: identification of cocaine and other illegal drugs of abuse

Fast assessment of oxo-biodegradable polyethylene film oxidation by surface-enhanced Raman scattering with in situ formation of a silver nanoparticle substrate

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