Methodologies for assessing morphosyntactic ability in people with Alzheimer's disease

Abstract

BackgroundThe detection and description of language impairments in neurodegenerative diseases like Alzheimer's Disease (AD) play an important role in research, clinical diagnosis and intervention. Various methodological protocols have been implemented for the assessment of morphosyntactic abilities in AD; narrative discourse elicitation tasks and structured experimental tasks for production, offline and online structured experimental tasks for comprehension. Very few studies implement and compare different methodological protocols; thus, little is known about the advantages and disadvantages of each methodology.AimsTo discuss and compare the main behavioral methodological approaches and tasks that have been used in psycholinguistic research to assess different aspects of morphosyntactic production and comprehension in individuals with AD at the word and sentence levels.MethodsA narrative review was conducted through searches in the scientific databases Google Scholar, Scopus, Science Direct, MITCogNet, PubMed. Only studies written in English, that reported quantitative data and were published in peer‐reviewed journals were considered with respect to their methodological protocol. Moreover, we considered studies that reported research on all stages of the disease and we included only studies that also reported results of a healthy control group. Studies that implemented standardized assessment tools were not considered in this review.Outcomes & ResultsThe main narrative discourse elicitation tasks implemented for the assessment of morphosyntactic production include interviews, picture‐description and story narration, whereas the main structured experimental tasks include sentence completion, constrained sentence production, sentence repetition and naming. Morphosyntactic comprehension in AD has been assessed with the use of structured experimental tasks, both offline (sentence‐picture matching, grammaticality judgment) and online (cross‐modal naming,speeded sentence acceptability judgment, auditory moving window, word detection, reading). For each task we considered studies that reported results from different morphosyntactic structures and phenomena in as many different languages as possible.Conclusions & ImplicationsOur review revealed strengths and weaknesses of these methods but also directions for future research. Narrative discourse elicitation tasks as well as structured experimental tasks have been used in a variety of languages, and have uncovered preserved morphosyntactic production but also deficits in people with AD. A combination of narrative discourse elicitation and structured production tasks for the assessment of the same morphosyntactic structure has been rarely used. Regarding comprehension, offline tasks have been implemented in various languages, whereas online tasks have been mainly used in English. Offline and online experimental paradigms have often produced contradictory results even within the same study. The discrepancy between the two paradigms has been attributed to the different working memory demands they impose to the comprehender or to the different parsing processes they tap. Strengths and shortcomings of each methodology are summarized in the paper, and comparisons between different tasks are attempted when this is possible. Thus, the paper may serve as a methodological guide for the study of morphosyntax in AD and possibly in other neurodegenerative diseases.WHAT THIS PAPER ADDSWhat is already known on this subject For the assessment of morphosyntactic abilities in AD, various methodological paradigms have been implemented: narrative discourse elicitation tasks and structured experimental tasks for production, and offline and online structured experimental tasks for comprehension. Very few studies implement and compare different methodological protocols; thus, little is known about the advantages and disadvantages of each methodology.What this paper adds to existing knowledge The paper presents an overview of methodologies that have been used to assess morphosyntactic production and comprehension of people with AD at the word and sentence levels. The paper summarizes the strengths and shortcomings of each methodology, providing both the researcher and the clinician with some directions in their endeavour of investigating language in AD. Also, the paper highlights the need for further research that will implement carefully scrutinized tasks from various experimental paradigms and will explore distinct aspects of the AD patients’ morphosyntactic abilities in typologically different languages.What are the potential or actual clinical implications of this work? The paper may serve as a reference point for (psycho‐)linguists who wish to study morphosyntactic abilities in AD, and for speech and language therapists who might need to apply morphosyntactic protocols to their patients in order to assess them or design appropriate therapeutic interventions for production and comprehension deficits.

Can we track the progression of Alzheimer's Disease via lexical-semantic variables in connected speech?

“…In particular, Boschi and colleagues suggest that pragmatics is better assessed during interviews, whereas lexical-semantic impairments are best assessed by using a picture description task. Varlokosta et al (2023) drew similar conclusions regarding picture description tasks, but they also indicated that discourse elicitation tasks are more constrained in assessing morphosyntactic production than structured experimental tasks. To get a more complete understanding of language preservations and impairments in AD patients, they therefore suggest using a combination of narrative discourse elicitation tasks and structured experimental tasks.…”

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“…The interaction between these processes has been shown to affect time reference more severely in people with aphasia (Bastiaanse, 2011;Faroqi-Shah and Friedman, 2015). On the other hand, studies in dementia populations have suggested that picture description tasks are more likely to reveal semantic and lexical retrieval deficits than morphosyntactic deficits (Sajjadi et al, 2012;Varlokosta et al, 2023). These findings appear to be supported by a study of participants with aphasia using picture description and interview tasks (Arslan et al, 2016).…”

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“…At mild-to-moderate stages, morphosyntactic production and comprehension impairments are evident both on word [17,18] and sentence levels [19,20]. Finally, phonology is the most well-preserved language domain in AD [9], although the production of phonemic paraphasias and neologisms is not rare [21].…”