Methodological quality and synthesis of case series and case reports

Murad, M. Hassan; Sultan, Shahnaz; Haffar, Samir; Bazerbachi, Fateh

doi:10.1136/bmjebm-2017-110853

Cited by 1,534 publications

(1,412 citation statements)

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“…For case reports on fetal therapy, quality of the included studies was assessed using the tool for evaluating the methodological quality of case series and case reports described by Murad et al …”

Section: Methodsmentioning

confidence: 99%

Perinatal outcome of pregnancies complicated by placental chorioangioma: systematic review and meta‐analysis

Buca

Iacovella

Khalil

et al. 2020

Ultrasound in Obstet & Gyne

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Objective To report the perinatal outcome of singleton pregnancies complicated by placental chorioangioma diagnosed on prenatal ultrasound. Methods MEDLINE, EMBASE, CINAHL and http://ClinicalTrials.gov databases were searched for studies reporting the outcome of pregnancies complicated by placental chorioangioma. Inclusion criteria were singleton pregnancy diagnosed with placental chorioangioma on prenatal ultrasound, with no other associated structural anomaly. The primary outcome was perinatal mortality. Secondary outcomes included associated non‐structural anomalies detected on prenatal ultrasound (including fetal hydrops, anemia, polyhydramnios, signs of hyperdynamic circulation and small‐for‐gestational‐age (SGA) fetus), SGA at birth, composite neonatal morbidity and preterm birth. Outcome was assessed separately in pregnancies undergoing and those not undergoing fetal therapy. Subanalyses were performed according to the presence of hydrops and the size of the tumor in all pregnancies diagnosed with chorioangioma. Random‐effects meta‐analyses of proportions were used to analyze the data. Results Twenty‐eight studies (161 pregnancies) were included. In pregnancies complicated by chorioangioma that did not undergo intervention, intrauterine death occurred in 8.2% (95% CI, 3.8–15.0%), while neonatal death and perinatal death occurred in 3.8% (95% CI, 1.0–8.1%) and 11.1% (95% CI, 5.0–19.4%), respectively. SGA at birth was present in 24.0% (95% CI, 13.5–36.5%) of cases, while preterm birth < 37 weeks complicated 34.1% (95% CI, 21.1–48.3%) of pregnancies. Composite neonatal morbidity occurred in 12.0% (95% CI, 4.5–22.3%) of cases. On ultrasound, signs of fetal hyperdynamic circulation were present in 21.0% (95% CI, 9.6–35.3%) of cases, while peak systolic velocity in the fetal middle cerebral artery was increased in 20.6% (95% CI, 10.9–32.3%). Subanalysis according to the size of chorioangioma, including both pregnancies that did and those that did not undergo intervention, showed a progressive increase in the occurrence of most of the outcomes explored with increasing size of the tumor. Furthermore, the prevalence of adverse perinatal outcome was high in pregnancies complicated by chorioangioma presenting with fetal hydrops. There was no randomized controlled trial comparing intervention vs expectant management in pregnancies complicated by chorioangioma with signs of fetal compromise (hydrops or hyperdynamic circulation). Overall, perinatal mortality occurred in 31.2% (95% CI, 18.1–46.1%) of fetuses undergoing in‐utero therapy, and 57.3% (95% CI, 39.2–74.4%) had resolution of hydrops or hyperdynamic circulation after treatment. Conclusions Placental chorioangioma is associated with adverse perinatal outcome. The size of the mass and presence of fetal hydrops are likely to be the main determinants of perinatal outcome in affected pregnancies. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.

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Section: Methodsmentioning

confidence: 99%

Perinatal outcome of pregnancies complicated by placental chorioangioma: systematic review and meta‐analysis

Buca

Iacovella

Khalil

et al. 2020

Ultrasound in Obstet & Gyne

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“…Given that there are no available validated tools to assess the methodological quality of case reports and case series, we derived items from the Newcastle‐Ottawa Scale (NOS) that were appropriate for this systematic review, and details are relayed in Appendix and Table S1. This tool was used in several systematic reviews with consistency among reviewers …”

Section: Methodsmentioning

confidence: 99%

Acute liver failure caused by hepatitis E virus genotype 3 and 4: A systematic review and pooled analysis

Haffar¹,

Shalimar

Kaur

et al. 2018

Liver International

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“…The evaluation tool presented by Murad and colleagues1 provides an accessible system for judging components of methodological quality in published case reports and series. Whereas the authors observe that their leading explanatory questions in the domain of causality are mostly applicable to drug-related adverse events, it is worth noting that additional, more generalisable factors have been identified.…”

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confidence: 99%

“…Narrative syntheses, as described by Murad and colleagues,1 enable interpretation within the metacausal (‘vertical’) dimension of the system, where insights into the ‘working principles’ of pathogenesis or pharmacology are obtained through cognitional assessment. For the causal (‘horizontal’) dimension, relationships will in most cases accord with the authors’ concept of causal gestalt correspondence , wherein cause and effect are not unified but appear intimately linked 2.…”

mentioning

confidence: 99%

“…Taken together, the two observations provide distinct and complementary evidence in favour of causal association. Crucially, their consolidation requires support through careful evaluation of report quality, particularly in the domains of ascertainment and reporting 1. Systematic reviews might thus apply the methodological quality evaluation tool1 in the process of report selection and appraisal and the causality assessment system2 in the process of cross-case analysis.…”

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confidence: 99%

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