Methodological optimisation of thymocyte isolation and cryopreservation of human thymus samples

Hagen, Ruth R.; Xu, Calvin; Koay, Hui-Fern; Konstantinov, Igor E.; Berzins, Stuart P.; Kedzierska, Katherine; van de Sandt, Carolien E.

doi:10.1016/j.jim.2024.113651

Journal of Immunological Methods

2024

DOI: 10.1016/j.jim.2024.113651

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Methodological optimisation of thymocyte isolation and cryopreservation of human thymus samples

Ruth R. Hagen,

Calvin Xu,

Hui-Fern Koay

et al.

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2024

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Thymic development of human natural killer T cells: recent advances and implications for immunotherapy

Pellicci,

Tavakolinia,

Perriman

et al. 2024

Front. Immunol.

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Invariant natural killer T (iNKT) cells are a subset of lipid-reactive, unconventional T cells that have anti-tumor properties that make them a promising target for cancer immunotherapy. Recent studies have deciphered the developmental pathway of human MAIT and Vγ9Vδ2 γδ-T cells as well as murine iNKT cells, yet our understanding of human NKT cell development is limited. Here, we provide an update in our understanding of how NKT cells develop in the human body and how knowledge regarding their development could enhance human treatments by targeting these cells.

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Thymic development of human natural killer T cells: recent advances and implications for immunotherapy

Pellicci,

Tavakolinia,

Perriman

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

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Methodological optimisation of thymocyte isolation and cryopreservation of human thymus samples

Cited by 1 publication

References 11 publications

Thymic development of human natural killer T cells: recent advances and implications for immunotherapy

Thymic development of human natural killer T cells: recent advances and implications for immunotherapy

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