Methanolic extract of Cucumis melo attenuates ethylene glycol-induced nephrolithiasis in Wistar rats

Afzal, Muhammad; Alharbi, Khalid Saad; Alzarea, Sami I.; Quazi, Anwarulabedin Mohsin; Zafar, Ameeduzzafar; Patel, Dhaval; Patel, Amish J.; Trivedi, Riddhi; Kazmi, Imran; Al-Abaasi, Fahad A.

doi:10.1007/s00240-021-01263-5

Cited by 7 publications

(9 citation statements)

References 18 publications

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“…Each component of LACTN has ameliorative role on urolithiasis and/or nephroprotective activity. Lens culinaris and Allium cepa have renoprotective effects [10,36]; while Cucumis melo, Triticum aestivum, Nasturtium o cinale have both nephroprotective and antiurolithiatic activities [15]. Collectively, the present study revealed that LACTN play a great action to minimize the stone formation and/or dissolve the already formed by many properties.…”

Section: Discussionmentioning

confidence: 63%

“…They added that potassium and citrate that present in Lens culinaris, Allium cepa, Cucumis melon, and Triticum aestivum considered alkali therapy that increasing urinary citrate that complexed with urinary calcium and prevent urolithiasis [39][40][41][42][43]. In addition, saponin that present in Allium cepa, Triticum aestivum, Cucumis melon have diuretic property which can leak the excessive calcium and oxalate ions through expulsion [2,15,44,45]. Also, presence of stone inhibitors like phytate in Triticum aestivum and Lens culinaris [17,46] aid to inhibit CaOx crystal formation due to formation of insoluble Ca-phytate complex in the gastrointestinal tract [47].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, C. melo resemble Coccinia indica and Benincasa hispida (Cucurbitaceae), so it contribute in alleviating urolithiasis by diuresis effect, lowering the excretion of uric acid, lowering of concentrations of stone forming components, and preventing renal peroxidative that nally reduce CaOx attachment to renal tubules [14,48,49]. Afzal et al [15] added that C. melo treatment decrease serum and urinary phosphate levels by inhibiting tissue non-speci c alkaline phosphatase (TNAP) enzyme. Recently, Patel et al [14] reported that Cucumis melo has antiurolithiasis effect due to its antimicrobial effect and its mucoproteins content that may act as anti-adherence and defensive barrier to the renal tubular layer.…”

Section: Discussionmentioning

confidence: 99%

“…Bulb onion enrich with quercetin and avonoids contents that increase its antioxidant activity [13]. Cucumis melo named as Musk melon has diuretic activity and can inhibit nephrolithiasis [14,15]. Triticum aestivum (wheat bran) is a cereal grass belonging to the family Gramineae.…”

Section: Introductionmentioning

confidence: 99%

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Anti-urolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Sayed

Soliman

Fahmy

et al. 2022

Preprint

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The present study assesses the role of polyherbal formula (LACTN) against sodium oxalate (NaOx) - stimulated urolithiasis prophylactic and curatively. Forty eight rats were separated into the following regimen’s groups. Groups I, II, III, and IV (prophylactic groups) divided as follows; Group I (control group) received saline as vehicle. Group II (urolithiatic group) received 70 mg NaOx / kg b.wt, i.p. Groups III and IV received LACTN and Cystone prophylactic (500 and 750 mg/kg b.wt, respectively) from 1st day to 7th day of urolithiasis induction. Groups V, VI, VII, and VIII (curative groups); these divided as the prophylactic regimes but LACTN and Cystone administered from 7th day to 14th day of urolithiasis induction. Urolithiatic rats co/post treated with LACTN and Cystone elevated the urinary volume significantly (P<0.05). Also, significant decreased (P<0.05) were observed in the serum and urine calcium and phosphate concentrations beside the increased magnesium value in urolithiatic rats co/post treated with LACTN. LACTN significantly (P<0.05) ameliorate serum and urine creatinine, urea, and uric acid concentration. Moreover, urolithiatic rats co/post treated with LACTN significantly (P<0.05) diminished MDA and increase GSH, GST, SOD, and CAT compared with urolithiatic rats. In conclusion, LACTN has anti-lithogenesis effect that may be due to its ability to remove the already presented stone and/or preventing the generation of extra calcium oxalate crystals. This action may be due to its components’ synergetic action that may provide encouraging combined formula to prevent/treat urolithiasis.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anti-urolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Sayed

Soliman

Fahmy

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Bulb onion enrich with quercetin and flavonoids contents that increase its antioxidant activity (Rampalli et al, 2013). Cucumis melo named as Musk melon has diuretic activity (Patel et al, 2021) and can inhibit nephrolithiasis (Afzal et al, 2021). Triticum aestivum (wheat bran) is a cereal grass belonging to the family Gramineae.…”

Section: Introductionmentioning

confidence: 99%

Antiurolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Sayed

Soliman

Fahmy

et al. 2023

JoBAZ

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Background The present study assesses the role of polyherbal formula (LACTN) against sodium oxalate (NaOx)—stimulated urolithiasis prophylactic and curative. Forty-eight rats were separated into the following regimen’s groups: Groups I, II, III, and IV (prophylactic groups). Group I (control group) received saline as vehicle. Group II (urolithiatic group) received 70 mg NaOx / kg b.wt, i.p. Groups III and IV received LACTN and cystone prophylactic (500 and 750 mg/kg b.wt, respectively) from 1st day to 7th day of urolithiasis induction. Groups V, VI, VII, and VIII (curative groups): these were divided into the prophylactic regimes, but LACTN and cystone were administered from 7th day to 14th day of urolithiasis induction. Results Urolithiatic rats co-/post-treated with LACTN and cystone elevated the urinary volume significantly (P < 0.05). Also, a significant decrease (P < 0.05) was observed in the serum and urine calcium and phosphate concentrations beside the increased magnesium value in urolithiatic rats co-/post-treated with LACTN. LACTN significantly (P < 0.05) ameliorates serum and urine creatinine, urea, and uric acid concentration. Moreover, urolithiatic rats co-/post-treated with LACTN significantly (P < 0.05) diminished MDA and increased GSH, GST, SOD, and CAT compared with urolithiatic rats. Conclusions LACTN has anti-lithogenesis effect that may be due to its ability to remove the already presenting stone and/or to prevent the generation of extra calcium oxalate crystals. This action may be due to its components’ synergetic action that may provide encouraging combined formula to prevent/treat urolithiasis.

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Sanjin Paishi Decoction improves the imbalance of gut microbiota and regulates MAPK signaling pathway to inhibit calcium oxalate stones in rats

et al. 2023

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Methanolic extract of Cucumis melo attenuates ethylene glycol-induced nephrolithiasis in Wistar rats

Cited by 7 publications

References 18 publications

Anti-urolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Anti-urolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Antiurolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Sanjin Paishi Decoction improves the imbalance of gut microbiota and regulates MAPK signaling pathway to inhibit calcium oxalate stones in rats

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