Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury

Matić, Sanja; Stanić, Snežana; Bogojević, Desanka; Vidaković, Melita; Grdović, Nevena; Dinić, Svetlana; Solujić, Slavica; Mladenović, Milan; Stanković, Nevena; Mihailović, Mirjana

doi:10.1016/j.mrgentox.2013.03.011

Cited by 52 publications

(42 citation statements)

References 63 publications

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“…Animal experiments with various plant extracts have shown protection against SB production in liver cells of pyrogallol-treated rats (at very high doses of extract) [34]; accelerated rejoining of γ-ray-induced DNA SBs [33]; and a decrease in pyrimidine dimers in the skin of UV(B)-irradiated mice [32]. …”

Section: Resultsmentioning

confidence: 99%

Polyphenols and DNA Damage: A Mixed Blessing

Azqueta

Collins

2016

Nutrients

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Polyphenols are a very broad group of chemicals, widely distributed in plant foods, and endowed with antioxidant activity by virtue of their numerous phenol groups. They are widely studied as putative cancer-protective agents, potentially contributing to the cancer preventive properties of fruits and vegetables. We review recent publications relating to human trials, animal experiments and cell culture, grouping them according to whether polyphenols are investigated in whole foods and drinks, in plant extracts, or as individual compounds. A variety of assays are in use to study genetic damage endpoints. Human trials, of which there are rather few, tend to show decreases in endogenous DNA damage and protection against DNA damage induced ex vivo in blood cells. Most animal experiments have investigated the effects of polyphenols (often at high doses) in combination with known DNA-damaging agents, and generally they show protection. High concentrations can themselves induce DNA damage, as demonstrated in numerous cell culture experiments; low concentrations, on the other hand, tend to decrease DNA damage.

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Section: Resultsmentioning

confidence: 99%

Polyphenols and DNA Damage: A Mixed Blessing

Azqueta

Collins

2016

Nutrients

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“…Myricetin was found with hepatoprotective properties against pyrogallolinduced toxicity. It prevented ROS production induced by tert-butylhydroperoxide in erythrocytes sampled from both normal subjects and sickle cell anemia patients treated with hydroxyurea (Henneberg et al, 2013;Matic et al, 2013). Myricetin also suppressed lipid peroxidation of hepatic microsomes derived from rats with deficient in D-atocopherol, which is a major lipid soluble antioxidant (Duthie & Morrice, 2012).…”

Section: Introductionmentioning

confidence: 97%

Attenuating effects of dihydromyricetin on angiotensin II-induced rat cardiomyocyte hypertrophy related to antioxidative activity in a NO-dependent manner

Meng

Yang

Yao

et al. 2014

Pharmaceutical Biology

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(2015) Attenuating effects of dihydromyricetin on angiotensin II-induced rat cardiomyocyte hypertrophy related to antioxidative activity in a NO-dependent manner, Pharmaceutical Biology, 53:6, 904-912, DOI: 10.3109/13880209.2014 Neonatal rat cardiomyocytes were pretreated with DMY (0-320 lM) followed with Ang II (100 nM) stimulation for 24 h, and then degree of hypertrophy was evaluated by cell surface analysis. Levels of reactive oxygen species (ROS) were measured with 2 0 ,7 0 -dichlorfluorescein-diacetate (DCFH-DA) fluorescent staining. Antioxidative activity was evaluated by malondialdehyde (MDA) level, superoxide dismutase (SOD) activity, and total antioxidant capacity (T-AOC). Cyclic guanosine monophosphate (cGMP) was determined with a radioimmunoassay. Results: Pre-incubation with DMY (20, 40, 80, and 160 lM) for 8 h, 12 h, 24 h, or 48 h decreased cell surface areas. It down-regulated mRNA expression of atrial natriuretic factor (1.95-to 1.24-fold) and b-myosin heavy chains (3.51-to 2.32-fold), reduced levels of MDA as well as increased SOD activity and T-AOC. Expression of SOD and thioredoxin were enhanced by DMY, whereas p22 phox and phosphorylation of mitogen-activated protein kinases were inhibited. Content of cGMP (0.54-to 0.80-fold) and phosphorylation of endothelial nitric oxide synthase at serine 1177 (0.70-to 1.05-fold) were augmented by DMY. Moreover, attenuating effect of DMY on hypertrophy was abolished when NO production was inhibited by L-NAME. Conclusion: Attenuating effects of DMY on Ang II-induced cardiomyocyte hypertrophy related to antioxidative activity in a NO-dependent manner. KeywordsCyclic guanosine monophosphate, endothelial nitric oxide synthase, mitogen-activated protein kinase, reactive oxygen species History

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“…Substantial evidences from literatures reveal that plants used in traditional medicine or as food can have mutagenic, cytotoxic and genotoxic effects in vitro and in vivo (Zink and Chaffin, 1998[41]; Celik, 2012[6]). Here, the effect of EtOH and aqueous extracts of L. montevidensis on DNA of human leukocytes was evaluated by the comet assay, which is regarded as a valuable biomarker of genotoxicity (Matić et al, 2013[24]). We found that both extracts (1-480 µg/mL) did not have genotoxic effect in relation to the control.…”

Section: Discussionmentioning

confidence: 99%