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Cited by 25 publications
(14 citation statements)
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“…Notably, we demonstrated that metformin intervention inhibits an elevation of osteoclast activity and oxidative stress in obesity-induced hyperglycemia mice. In agreement with the current findings, metformin was reported to suppress osteoclast differentiation in collagen-induced arthritic mice [ 65 ] and inhibit ROS generation under osteoporotic conditions [ 66 ]. As mentioned above, an elevation of oxidative stress contributes to osteoclastic bone resorption rather than osteoblastic bone formation.…”
Section: Discussionsupporting
confidence: 91%
“…Notably, we demonstrated that metformin intervention inhibits an elevation of osteoclast activity and oxidative stress in obesity-induced hyperglycemia mice. In agreement with the current findings, metformin was reported to suppress osteoclast differentiation in collagen-induced arthritic mice [ 65 ] and inhibit ROS generation under osteoporotic conditions [ 66 ]. As mentioned above, an elevation of oxidative stress contributes to osteoclastic bone resorption rather than osteoblastic bone formation.…”
Section: Discussionsupporting
confidence: 91%
“…Metformin, which is commonly used to combat hyperglycemia, has also been shown to affect bone regeneration. Metformin increases autophagy in BMSCs under hypoxic conditions and upregulates the osteogenic markers Runx2, osteocalcin, and alkaline phosphatase to significantly accelerate the formation of new bone ( 147 , 148 ). Simvastatin, a serum cholesterol-lowering drug, has been shown to promote bone regeneration.…”
Section: Implications For Treatmentmentioning
confidence: 99%
“…The in vitro study revealed that metformin (0.05–0.3 mM) could protect mitochondrial function and antagonize oxidative stress damage by upregulating SIRT3 expression, and ultimately alleviate H 2 O 2 (0.2 mM)-induced apoptosis in osteoblasts ( Yang et al, 2021 ). Similarly, another study found that metformin (50 mM) promoted cell differentiation and new bone formation in bone mesenchymal stem cells by a mechanism related to the regulation of autophagy, proliferation, and oxidative stress by metformin ( Lin et al, 2020 ) In vivo experiments, oral metformin promoted the release of osteoprotegerin (OPG) in osteoblasts, thereby inhibiting the differentiation of macrophages to osteoclasts and reducing bone loss in the de-ovalized osteoporotic rat model ( Mai et al, 2011 ). In a glucocorticoid-induced osteoporosis model, oral metformin (200 mg/kg/day) had a dual protective effect, i.e., it both inhibited bone resorption and promoted bone formation in trabeculae ( Zhao et al, 2019 ), Another study identified a similar osteoprotective effect of metformin in ketogenic diet-induced osteoporosis mice ( Liu et al, 2019 ).…”
Section: Protective Effects Of Metformin In the Musculoskeletal Systemmentioning
confidence: 99%