Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading <i>Akkermansia muciniphila</i> and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

Cuesta-Zuluaga, Jacobo de la; Mueller, Noel T.; Corrales-Agudelo, Vanessa; Velásquez-Mejía, Eliana P.; Carmona, Jenny Andrea; Abad, José M.; Escobar, Juan S.

doi:10.2337/dc16-1324

Cited by 560 publications

(478 citation statements)

References 37 publications

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“…Interestingly, metformin treatment may improved the glycemic profile modifying gut microbiota, and accumulating evidence suggests that the gut microbiota is an important factor in mediating the development of obesity-related metabolic disorders, including type 2 diabetes [57,58]. For example, high-fat diet (HFD)-fed C57BL/6 mice treated with metformin showed a higher abundance of the mucin-degrading bacterium Akkermansia muciniphila with an increase of the number of mucin-producing goblet cells due to metformin treatment [59,60,61]. Other studies in animal models disclosed an increase of Clostridium cocleatum [60], Butyrivibrio, Bifidobacterium bifidum, and Megasphaera [61].…”

Section: Discussionmentioning

confidence: 99%

“…For example, high-fat diet (HFD)-fed C57BL/6 mice treated with metformin showed a higher abundance of the mucin-degrading bacterium Akkermansia muciniphila with an increase of the number of mucin-producing goblet cells due to metformin treatment [59,60,61]. Other studies in animal models disclosed an increase of Clostridium cocleatum [60], Butyrivibrio, Bifidobacterium bifidum, and Megasphaera [61]. Similar data are hypothesized in human with T2DM [62].…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Evaluation of Metformin and/or Metformin Plus a New Polysaccharide Complex in Treating Severe Hyperinsulinism and Insulin Resistance in Obese Children and Adolescents with Metabolic Syndrome

et al. 2017

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Background: Pharmacological treatment of obesity and glucose-insulin metabolism disorders in children may be more difficult than in adults. Thus, we evaluate the effects of metformin in comparison with metformin plus a polysaccharide complex (Policaptil Gel Retard®, PGR) on body weight and metabolic parameters in obese children and adolescents with metabolic syndrome (MetS). Patients and methods: We retrospectively collected 129 children and adolescents (67 girls, 62 boys; median age 12.6 years) treated for a minimum of two years with metformin and low glycemic index (LGI) diet. Of these, 71 patients were treated with metformin plus PGR after at least 12 months of metformin alone. To minimize the confounding effect of the LGI on auxological and metabolic parameters, the patients were compared with age-, sex-, and BMI-matched control group with obesity and MetS (51 subjects; 24 males, 27 females) treated only with a LGI diet. Assessments included lipids, glucose and insulin (fasting and after oral glucose tolerance test) concentrations. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Matsuda, insulinogenic and disposition indices were calculated. Results: Metformin treatment led to a significant reduction in BMI SDS (p < 0.0001), with a significant difference in ΔBMI SDS between patients and controls (p < 0.0001). Moreover, metformin treated patients showed a reduction in HOMA-IR (p < 0.0001), HbA1c levels (p < 0.0001) and a significant increase in Matsuda index (p < 0.0001) in respect to the reduction discovered in controls (p < 0.05). Moreover, in contrast to the group treated with metformin alone and controls, patients treated with metformin plus PGR showed a further reduction in BMI SDS (p < 0.0001), HOMA-IR (p < 0.0001), HbA1c (p < 0.0001), total, HDL and LDL cholesterol (p < 0.0001), as well as an increase in Matsuda (p < 0.0001), disposition (p < 0.005) and insulinogenic (respectively, p < 0.05 and p < 0.0001) indices. Conclusions: Metformin appears to show short-term efficacy in reducing BMI, adiposity and glucose and insulin parameters in obese children and adolescents with MetS. However, PGR added to metformin may be useful to potentiate weight loss and to improve glucose-insulin metabolism and adiposity parameters in these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Retrospective Evaluation of Metformin and/or Metformin Plus a New Polysaccharide Complex in Treating Severe Hyperinsulinism and Insulin Resistance in Obese Children and Adolescents with Metabolic Syndrome

et al. 2017

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“…Recent studies suggest that the microorganisms are involved in mediating the beneficial effects of metformin on glucose metabolism. Metformin shifts gut microbiota composition through the enrichment of mucin-degrading A. muciniphila as well as several short- chain fatty acid-producing microbiota including Butyrivibrio , Bifidobacterium bifidum , Megasphaera , and Prevotella (194). Overall, there is substantial evidence of the key role of microbiota in obesity and its adverse effects.…”

Section: Role Of Microbiome In Obesitymentioning

confidence: 99%

The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists

et al. 2017

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Humans consider themselves discrete autonomous organisms, but recent research is rapidly strengthening the appreciation that associated microorganisms make essential contributions to human health and well-being. Each person is inhabited and also surrounded by his/her own signature microbial cloud. A low diversity of microorganisms is associated with a plethora of diseases including allergy, diabetes, obesity, arthritis, inflammatory bowel diseases and even neuropsychiatric disorders. Thus, an interaction of microorganisms with the host immune system is required for a healthy body. Exposure to microorganisms from the moment we are born and appropriate microbiome assembly during childhood are essential for establishing an active immune system necessary to prevent disease later in life. Exposure to microorganisms educates the immune system, induces adaptive immunity and initiates memory B and T cells that are essential to combat various pathogens. The correct microbial-based education of immune cells may be critical in preventing the development of autoimmune diseases and cancer. This review provides a broad overview of the importance of the host microbiome and accumulating knowledge of how it regulates and maintains a healthy human system.

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“…At the same time, there were reports of a favorable therapeutic effect of the association of metformin and GLP-1 preparations [26], and that of a certain role of microbiota (a set of microbes in the intestine) [9].…”

Section: том 13 № 5 2017mentioning

confidence: 99%

Роль Імунної Системи У Механізмі Терапевтичної Дії Метформіну У Хворих На Цукровий Діабет 2-Го Типу

Zak¹,

Orlenko²,

Popova³

et al. 2021

Mìžnarodnij endokrinologìčnij žurnal

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Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

Cited by 560 publications

References 37 publications

Retrospective Evaluation of Metformin and/or Metformin Plus a New Polysaccharide Complex in Treating Severe Hyperinsulinism and Insulin Resistance in Obese Children and Adolescents with Metabolic Syndrome

Retrospective Evaluation of Metformin and/or Metformin Plus a New Polysaccharide Complex in Treating Severe Hyperinsulinism and Insulin Resistance in Obese Children and Adolescents with Metabolic Syndrome

The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists

Роль Імунної Системи У Механізмі Терапевтичної Дії Метформіну У Хворих На Цукровий Діабет 2-Го Типу

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