2012
Abstract: Metformin, an oral anti-diabetic drug, is being considered increasingly for treatment and prevention of cancer, obesity as well as for the extension of healthy lifespan. Gradually accumulating discrepancies about its effect on cancer and obesity can be explained by the shortage of randomized clinical trials, differences between control groups (reference points), gender- and age-associated effects and pharmacogenetic factors. Studies of the potential antiaging effects of antidiabetic biguanides, such as metform…
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Cited by 76 publications
(63 citation statements)
References 83 publications
(127 reference statements)
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“…Aging is the most important "risk factor" of cancer and any interventions that slow aging also delay cancer. 44,[48][49][50][51][52] Rapamycin slows down aging in numerous organisms, including those that do not die from cancer. [53][54][55][56][57][58][59] As an anti-cancer and anti-aging agent, rapamycin can delay cancer not only directly but also indirectly: by slowing down aging.…”
Section: Introductionmentioning
confidence: 99%
“…Aging is the most important "risk factor" of cancer and any interventions that slow aging also delay cancer. 44,[48][49][50][51][52] Rapamycin slows down aging in numerous organisms, including those that do not die from cancer. [53][54][55][56][57][58][59] As an anti-cancer and anti-aging agent, rapamycin can delay cancer not only directly but also indirectly: by slowing down aging.…”
Section: Introductionmentioning
confidence: 99%
“…AMPK activation slows aging in C. elegans (Apfeld et al 2004;Mair et al 2011) and is being considered as a calorie restriction mimetic (Ingram et al 2006). Therefore, metformin has been used for life extension in mammals and, in some studies although not all, has demonstrated gerosuppressive effects (Smith et al 2010;Anisimov et al 2011;Berstein 2012). Interestingly, 12 days of treatment with metformin has been shown to increase adult neurogenesis and spatial memory (Wang et al 2012).…”
Section: Introductionmentioning
confidence: 99%
“…), hormones (GH, thyroid hormones, adrenal and sexual hormones, melatonin [50]), bioregulatory peptides (timalin, epithalmin), biguanides (metformin, fenformin) [77], adaptogens (ginseng [48]). Sirolimus or rapamycin, described as immunosuppressive and antitumoral drug has been shown to be also an anti-ageing drug [41] whose goal is the TOR gene in yeast [43] and mTOR gene, its mammalian correspondent, also known as FK506 factor or FRAP1, a serine/threonine kinase that regulates cell growth, viability, mobility, protein synthesis and gene transcription [31,45,78].…”
Section: Geroprotectors Geroprotectors Geroprotectors Geroprotectorsmentioning
confidence: 99%
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