Metastatic Tumors of the Central Nervous System

Abstract

METASTATIC Tumors of the central nervous system are not uncommon; their diagnosis is often difficult, and the pertinent literature, as Globus1 commented, is relatively meager. It therefore was thought worthy of interest to review the material in the laboratory of neuropathology of the Philadelphia General Hospital. These cases are drawn not only from the neurologic and neurosurgical wards but from the medical, surgical and radiologic services as well.The cases of metastatic involvement of the central nervous system have been grouped on the following basis.Group 1.\p=m-\Forty-two cases in which the metastatic involvement apart from extension to the regional lymph nodes, was observed only in the brain in the form of discrete metastatic nodules, either single or multiple, ranging in size from 1 to 9 cm. In this group the clinical signs and symptoms simulated those of a primary intracerebral lesion. Group 2.\p=m-\Sixty-seven cases in which the metastatic involvement of the central nervous system was a manifestation of general carcinomatosis, with metastatic lesions found in distant visceral organs and the skeleton as well as in the central nervous system. Group 3.-Nineteen cases in which the metastatic involvement of the nervous system was a result of direct extension from a primary site con¬ tiguous with the nervous system, such as the nasal accessory sinuses, naso¬ pharynx and scalp.Group 4.-Twenty-two cases in which the metastatic involvement of the nervous system was limited to the spinal meninges. In this study only the cases in group 1, in which the metastatic lesion simulated a primary intracerebral lesion, are considered. The other groups will be treated in greater detail in future presentations.

Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

“…Almost all primary malignant cardiac tumors are sarcomas, most frequently angiosarcomas, and usually originate in the right atrium or pericardium. Brain metastasis are generally considered to be a rare ocurrence in patients with non-hematologic sarcomas, and most reviews of cerebral metastatic disease do not include metastatic sarcoma [13][14][15] .…”

Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

“…Almost all primary malignant cardiac tumors are sarcomas, most frequently angiosarcomas, and usually originate in the right atrium or pericardium. Brain metastasis are generally considered to be a rare ocurrence in patients with non-hematologic sarcomas, and most reviews of cerebral metastatic disease do not include metastatic sarcoma [13][14][15] .…”

Posterior Fossa Metastases Simulating Primary Tumors

“…In contrast to the many studies (Globus & Selinsky (1927), Grant, Davidsen & Horwitz (1930), Fried & Buckley (1930), Craig, Wolfman & Kernohan (1939), King & Ford (1942), Tom (1946), Kenneth ef al. (19481, Lesse & Netsky (1954), Rupp (1948), Klass & Bickford (1958), Forlow (1959), Simionescu (1960), Richards & Mcliissock (1963) describing rnctastatic lesions in the cerebrum prescnting as primary tumors, no attention has been focused on a similar phenomenon involving nietastascs in the posterior fossa. Thc sinall number of case rcports available have usually been part of an overall study of cerebral mctastascs.…”

Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

“…Almost all primary malignant cardiac tumors are sarcomas, most frequently angiosarcomas, and usually originate in the right atrium or pericardium. Brain metastasis are generally considered to be a rare ocurrence in patients with non-hematologic sarcomas, and most reviews of cerebral metastatic disease do not include metastatic sarcoma [13][14][15] .…”

Posterior Fossa Metastases Simulating Primary Tumors

“…In contrast to the many studies (Globus & Selinsky (1927), Grant, Davidsen & Horwitz (1930), Fried & Buckley (1930), Craig, Wolfman & Kernohan (1939), King & Ford (1942), Tom (1946), Kenneth ef al. (19481, Lesse & Netsky (1954), Rupp (1948), Klass & Bickford (1958), Forlow (1959), Simionescu (1960), Richards & Mcliissock (1963) describing rnctastatic lesions in the cerebrum prescnting as primary tumors, no attention has been focused on a similar phenomenon involving nietastascs in the posterior fossa. Thc sinall number of case rcports available have usually been part of an overall study of cerebral mctastascs.…”

Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

“…Almost all primary malignant cardiac tumors are sarcomas, most frequently angiosarcomas, and usually originate in the right atrium or pericardium. Brain metastasis are generally considered to be a rare ocurrence in patients with non-hematologic sarcomas, and most reviews of cerebral metastatic disease do not include metastatic sarcoma [13][14][15] .…”

Posterior Fossa Metastases Simulating Primary Tumors

“…In contrast to the many studies (Globus & Selinsky (1927), Grant, Davidsen & Horwitz (1930), Fried & Buckley (1930), Craig, Wolfman & Kernohan (1939), King & Ford (1942), Tom (1946), Kenneth ef al. (19481, Lesse & Netsky (1954), Rupp (1948), Klass & Bickford (1958), Forlow (1959), Simionescu (1960), Richards & Mcliissock (1963) describing rnctastatic lesions in the cerebrum prescnting as primary tumors, no attention has been focused on a similar phenomenon involving nietastascs in the posterior fossa. Thc sinall number of case rcports available have usually been part of an overall study of cerebral mctastascs.…”