1979
DOI: 10.1001/archderm.115.10.1214
|View full text |Cite
|
Sign up to set email alerts
|

Metastatic squamous cell carcinoma of the lip. Occurrence in blacks with discoid lupus erythematosus

Abstract: In two black patients, squamous cell carcinoma of the lip developed within lesions of discoid lupus erythematosus (DLE). The association of DLE and squamous cell carcinoma is unusual in blacks, as is the anatomical site involved in these cases. Enhanced metastatic potential may be present when squamous cell carcinoma arises in DLE of the lips.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

1
13
0
1

Year Published

2007
2007
2016
2016

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 16 publications
(15 citation statements)
references
References 0 publications
1
13
0
1
Order By: Relevance
“…Discoid lupus erythematosus is one of the predisposing conditions for squamous cell carcinoma [10]. Exposure to actinic radiation [1], and carcinogenic agents such as cytotoxics or radiation [8] were the main causes in this case.…”
Section: Discussionmentioning
confidence: 78%
See 1 more Smart Citation
“…Discoid lupus erythematosus is one of the predisposing conditions for squamous cell carcinoma [10]. Exposure to actinic radiation [1], and carcinogenic agents such as cytotoxics or radiation [8] were the main causes in this case.…”
Section: Discussionmentioning
confidence: 78%
“…Dabski et al [9] and Martin and Rosen [10] reported that there was high metastatic potential in squamous cell carcinomas that arise in DLE. Most of the authors preferred excision as treatment if a squamous cell carcinoma complicated DLE [1].…”
Section: Discussionmentioning
confidence: 99%
“…2 1 death has also been reported from mul ple metastases. 13 The risk of a pa ent with DLE developing systemic lupus erythematosus (SLE) is small. It varies from 1.3% to about 6.5%.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, it has been proposed that the use of antimalarials such as chloroquine would seem to Kasai et al 21 n/a n/a 1 n/a n/a n/a Lower lip Martin et al 14 DLE n/a 2 n/a n/a SCC Lip Handlers et al 12 DLE F 1 24 n/a SCC Lower lip Lipkin et al 16 SLE n/a 1 n/a n/a SCC n/a Voigtla¨nder et al 22 have a protective effect against malignant neoplasias. The mechanism of this possible 'protection' consists in the prevention of mutations in cells with a high mitotic rate, inhibition of the telomerase (implicated in the indefinite replication of tumour cells), increase of synthesis of p53 and improvement of cell repair of DNA; unfortunately smoking greatly reduces the efficiency of these drugs.…”
Section: Discussionmentioning
confidence: 99%