Metastatic Silicone Granuloma: Lupus Miliaris Disseminatus Faciei-like Facial Nodules and Sicca Complex in a Silicone Breast Implant Recipient

Periorbital lipogranuloma: a previously unknown complication of autologous fat injections for facial augmentation

“…Microdroplets of damaged and liquefied fat after injection of cryopreserved fat may undergo phagocytosis and be transported to other sites through lymphatics. Previous reports on lymphatic spread of injected silicone to distant sites24 25 support the possibility of lymphatic migration in our patients.…”

Cryopreserved Autologous Fat Injections as a Filler Agent for Facial Augmentation: Are They Still Safe?

“…Interestingly, in previously reported cases, all granulomas appeared in the eyelids, and were mainly explained by local migration and possible lymphatic migration of cryopreserved fat 3. Lymphatic spread of injected silicone has been previously reported,5 and in our case, granulomas in the perioral area were located in the buccinator lymph node area, supporting the possibility of lymphatic spread.…”

Clinical characteristics of patients with a periorbital mass after autologous fat injection for facial augmentation and short-term outcomes of steroid treatment

“…5 In addition, damaged adipocytes can move through the lymphatic system, which is also observed with injection of synthetic fillers. 11,14 In the present study, the most common site of fat injection was the forehead (90%), and most In the present study, 77.5 % patients showed satisfactory outcomes with steroid therapy alone.…”