Metastatic signet ring cell gastric carcinoma presenting as an infrarenal aortic aneurysm

Menzel, Thomas; Peters, Katharina; Hammerschmidt, Stefan; Ritter, Oliver

doi:10.1007/s10120-004-0305-4

Cited by 4 publications

(3 citation statements)

References 16 publications

(16 reference statements)

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“…Literature reports rare cases of single localization in abdominal cavity that may be resected. Menzel [3] reported a case of infrarenal aortic aneurysm whose detection permitted to discover gastric carcinoma. A similar condition is reported by Shimoyama [4] who diagnosed gastric cancer after nephroureterectomy for hydronephrosis due to ureteral metastasis.…”

Section: Discussionmentioning

confidence: 99%

Local recurrence of gastric cancer after total gastrectomy: an unusual presentation

et al. 2012

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A 71 years old Italian man had type 3 gastric cancer of the greater curvature. Total gastrectomy with splenectomy and D2 lymph node dissection were performed. After discharge chemotherapy ELF regimen was administred for 6 months. After 16 months from the operation a local recurrence was discovered by CT scan. Surgical en-bloc resection was performed removing pancreatic tail, splenic colic flexure and a portion of left diaphragm. Histological examination confirmed local recurrence of gastric adenocarcinoma infiltrating pancreas, colon and diaphragm with lymph node metastasis.

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Section: Discussionmentioning

confidence: 99%

Local recurrence of gastric cancer after total gastrectomy: an unusual presentation

et al. 2012

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“…Knochenmark [40] erysipelartige Hautläsionen Haut [31] umbilikaler Tumor Bauchnabel [43] Dysästhesien, Induration Glutealmuskel [39] mammärer Tumor Mamma [36] Dyspnö Lymphangiosis carcinomatosa der Lunge [35] Heiserkeit, Husten mediastinale Lymphknotenmetastase mit Trachaelstenose [38] infrarenales Aneurysma Lymphangiosis carcinomatosa der Aortenwand [42] antibiotikaresistente Dysurie Blase [32] vaginale Blutung Zervix, Uterus [41] Nach der gastroskopisch-bioptisch gesicherten Diagnose eines Magen-Ca sollten Staginguntersuchungen durchgeführt werden.…”

Section: Quelleunclassified

Magenkarzinom in der Schwangerschaft - Ein Fallbericht

Brüggmann

Mk²,

Bohle³

et al. 2006

Zentralbl Gynakol

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Nausea and vomiting are common sufferings of pregnant woman. No gynaecologist would consider carcinoma of the stomach as a probable differential diagnosis according the extremely rare probability of this disease during pregnancy. Consequently, a late diagnosis in pregnancy can result in spreading throughout the whole abdomen. In this advanced stage, it is only possible to recommend palliative care to the patient followed by short survival. Fetal metastasis is a rare entity, therefore caesarean section and chemotherapy should not be performed until fetal maturity. If vomiting and nausea are prolonged after the sixteenth week of pregnancy a malignant disease of the stomach should be excluded. Only in case of short delay between symptoms and diagnosis, the stomach cancer can be resected totally followed by a better overall survival of the patient.

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“… 9 The diagnosis requires pathological examination, gastrointestinal examination (consisting of an abdominal computed tomography [CT] scan, esophagogastroduodenoscopy, and colonoscopy), and specialized staining processes that facilitate detection of the primary lesion of prostate cancer. 10 11 Patients with primary SRCC of the prostate usually have a poor prognosis, and a standard therapy has not been proposed due to the low number of cases. According to electronic resources, 196 cases of primary SRCC of the prostate have been reported to date.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical analysis of PD-L1 and tumor-infiltrating immune cells expression in the tumor microenvironment of primary signet ring cell carcinoma of the prostate

Fan¹,

Liu²,

Teng³

et al. 2022

Asian Journal of Andrology

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Primary signet ring cell carcinoma (SRCC) of the prostate is a rare neoplasm. However, its potential tumorigenic mechanism, clinicopathological features, and prognostic outcome have not been systematically described. To determine the pathogenic mechanism, we detected distributions of programmed cell death-ligand 1 (PD-L1), programmed death 1 (PD-1), and cellular components in the tumor microenvironment, including tumor-infiltrating lymphocytes (CD4 and CD8), tumor-associated macrophages (TAMs; CD163 and CD68), and tumor-associated fibroblasts (vimentin and alpha-smooth muscle actin [α-SMA]), in tumor tissues from four patients with primary prostatic SRCC compared with corresponding adjacent tissues and tumor tissues from 30 patients with prostate adenocarcinoma (PCa) by immunohistochemical staining. We found higher expression of PD-L1, CD163, and CD68 in primary SRCC specimens than that in both corresponding adjacent nontumor specimens and PCa specimens with different Gleason scores, indicating that TAMs may participate in the malignant biological behavior of primary SRCC of the prostate. For further analysis, we searched electronic journal databases and Surveillance, Epidemiology, and End Results (SEER) to identify 200 eligible patients including our four cases. According to Kaplan–Meier survival curve analysis, patients <68 years old, with radical prostatectomy (RP), Gleason score of 7–8, and lower clinical stage had longer overall survival (OS). Moreover, Cox multivariate analysis indicated that race (hazard ratio [HR] = 1.422), surgical approach (HR = 1.654), and Gleason score (HR = 2.162) were independent prognostic factors for OS. Therefore, primary SRCC of the prostate represents a distinct and aggressive subtype of prostate cancer associated with a higher distribution of PD-L1 and TAMs, which warrants further clinical investigation.

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Metastatic signet ring cell gastric carcinoma presenting as an infrarenal aortic aneurysm

Cited by 4 publications

References 16 publications

Local recurrence of gastric cancer after total gastrectomy: an unusual presentation

Local recurrence of gastric cancer after total gastrectomy: an unusual presentation

Magenkarzinom in der Schwangerschaft - Ein Fallbericht

Immunohistochemical analysis of PD-L1 and tumor-infiltrating immune cells expression in the tumor microenvironment of primary signet ring cell carcinoma of the prostate

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