Metastatic Hidradenocarcinoma: Efficacy of Capecitabine

Objective Clinical and Radiological Response under Sunitinib in a Case of Thigh Hidradenocarcinoma

“…Usual treatment for Hidrad is wide local excision, with or without lymph node dissection [5][6][7]. Adjuvant and/or palliative radiation therapy is rarely used [7]. Salvage chemotherapy in locoregional and/or metastatic relapse showed a modest efficacy, like we observed for our patient that received 3 lines of treatment [7].…”

“…Adjuvant and/or palliative radiation therapy is rarely used [7]. Salvage chemotherapy in locoregional and/or metastatic relapse showed a modest efficacy, like we observed for our patient that received 3 lines of treatment [7]. After metastatic progression, we opted for a 4 th line oral sunitinib, an oral tyrosine kinase inhibitor having an antiangiogenic and antitumor activity.…”

Malignant nodular hidradenoma of the skin: report of seven cases

“…, we excised lesions with a 1‐cm margin on the first occasion followed by a further margin of 1 cm from the suture border. The high local recurrence rate of our cases (86%) is probably related to the narrower excision margins used by us with respect to other authors 18,26 . However, 3 of 7 of our cases had primitive lesions in the head and neck region, where surgery is more problematical than in other parts of the body.…”

“…The high local recurrence rate of our cases (86%) is probably related to the narrower excision margins used by us with respect to other authors. 18,26 However, 3 of 7 of our cases had primitive lesions in the head and neck region, where surgery is more problematical than in other parts of the body. Because of the aggressive nature of MNH and its spread through regional lymphatics, many authors advocate prophylactic lymph node dissection, especially for large, recurrent or anaplastic tumours.…”

“…In both cases, this treatment seemed effective in preventing recurrence. Chemotherapy is only mentioned in a few individual or small‐series case reports, and its adjuvant role seems to warrant reassessment 24,26,27 . None of the four patients from our group who underwent chemotherapy seemed to benefit.…”