Metastatic Crohn's disease. Report of 3 cases with special reference to histopathologic findings

Granulomatous rosacea and Crohn’s disease in a patient homozygous for the Crohn‐associated NOD2/CARD15 polymorphism R702W

“…This possibility was extensively discussed with the dermatopathologist. However, histopathological examination of our patient's skin lesions did not show significant necrobiosis, vasculitis or neutrophil infiltrates, features that one would expect in cutaneous Crohn (8). Rather, the presence of plasma cells and histiocytes in combination with perifollicular distribution and the deep dermal infiltrate was felt to be consistent with the diagnosis of granulomatous rosacea.…”

Metastatic Crohn's disease – Proposition of a clinicopathological correlation

“…Interestingly, the granuloma presents a vascular tropism in the majority of the cases of the literature. A true vasculitis with fibrinoid necrosis, as in our first case, has been identified in eight reports 4–7 . This aspect of vasculitis can be a misleading, so the diagnosis becomes a difficult one, in particular when the CD is not known.…”

Granulomatous vasculitis in Crohn's disease: a clinicopathologic correlate of two unusual cases

“…The granulomata are frequently associated with a mixed, often eosinophil‐rich, infiltrate that commonly shows a superficial and deep perivascular distribution. Less frequent findings include a lichenoid infiltrate, necrosis and massive dermal edema 3,5 . True granulomatous vasculitis with intramural inflammatory cells and fibrin deposition, as seen here, has been infrequently reported.…”