Metastatic cervical carcinoma to the thyroid gland: A rare diagnosis

Varlı, Bulut; Taşkın, Salih; Ortaç, Fırat

doi:10.1016/j.tjog.2019.01.024

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…Metastasis of cervical cancer to the thyroid gland is rare, with only 14 cases having been reported, including our case ( Table 1 ) 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 . The mean age of the reported patients was 55 years (range: 36–72 years; n = 14).…”

Section: Discussionmentioning

confidence: 74%

Thyroid metastasis from cervical carcinoma

Hayashi¹,

Kumai²,

Michizuka³

et al. 2023

Brazilian Journal of Otorhinolaryngology

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Section: Discussionmentioning

confidence: 74%

Thyroid metastasis from cervical carcinoma

Hayashi¹,

Kumai²,

Michizuka³

et al. 2023

Brazilian Journal of Otorhinolaryngology

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“…Cervical cancer metastasising to the thyroid gland is very rare and only a handful of cases have been reported [ 2 ]. These cases are summarised in Table 1 [ 2 , 4 , 6 – 9 ]. Sometimes, it may be clinically difficult to differentiate the origin of the tumour, whether it is primary or secondary.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the uterine cervix metastasising to the thyroid gland: a case report

Ravindrakumar¹,

Thalahitiyage²,

Harivallavan³

et al. 2021

surg case rep

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Background Carcinoma of the uterine cervix (cervical cancer) metastasising to the thyroid gland is a rare phenomenon and only a few cases have been reported. We discuss a patient with cervical cancer presenting with thyroid and cervical lymph node metastasis, exploring the diagnostic difficulty, evaluation and treatment options. Case presentation A previously well 56-year-old female presented with multiple neck lumps for 4 months duration. Examination of the neck revealed multiple firm/hard left cervical lymph nodes with a hard thyroid nodule. There were no abdominal masses however, vaginal examination revealed a hard, unhealthy cervix. Contrast enhanced computed tomography revealed a growth in the uterine cervix with lymph node enlargement in the abdomen, chest and neck along with multiple thyroid nodules. Biopsy of the cervix and cervical lymph node and fine needle aspiration cytology of the thyroid nodules were performed, all revealing a squamous cell carcinoma. Pan-endoscopy performed to rule out any concurrent cancer of the upper aerodigestive tract was negative. The patient was started on palliative therapy, but succumbed to the disease after 6 months. Discussion and conclusion Patients who present with a thyroid nodule along with multiple cervical lymph nodes should be thoroughly assessed for possible metastatic cancers. Metastasis to the thyroid gland indicates a poor prognosis in the background of carcinoma or the uterine cervix. More awareness among the public and primary care providers is necessary regarding freely available screening programmes for early detection of cervical cancer.

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“…Direct infiltration of the thyroid by adjacent carcinoma is usually discovered at the time of surgery on histological examination. In addition to direct infiltration, squamous cell carcinoma could metastasize to thyroid from organs such as lung or rarely from cervix (Lam & Lo 1998, Varlı et al 2019.…”

Section: Differential Diagnosesmentioning

confidence: 99%

Squamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classification

Lam

2020

Endocrine-Related Cancer

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The aim is to review the features of 117 primary squamous cell carcinomas of thyroid which meet the histological criteria of the World Health Organization classification of endocrine tumours. The carcinomas occur in 83 women and 34 men (female to male ratio is 2.4 to 1) and with median age at presentation of 64. Half of these squamous cell carcinomas of thyroid were moderately differentiated. PAX-8 protein is a sensitive marker for confirming the thyroid origin of the carcinoma. The carcinoma is also positive for p63, p40, cytokeratins 5/6, 7,19 and negative for cytokeratins 20 and 10/13. P53 overexpression is common. The most important differential diagnosis is direct infiltration or metastatic involvement by squamous cell carcinoma from other organs. Limited mutation analysis revealed BRAF mutation in some squamous cell carcinomas of the thyroid. The genetic profile appears to be different from anaplastic thyroid carcinomas. Primary squamous cell carcinoma of thyroid had lymph node involvement in 59% and distant metastases in 26%. The median survival of the patients was 8 months. Curative surgery offers the best survival for the patients with the carcinoma. To conclude, primary squamous cell carcinoma of the thyroid gland has distinctive clinical, pathological and molecular profiles. It is important to recognize this unique variant of thyroid carcinoma for possible curative surgical resection and to do more genomic works on the entity to uncover the molecular pathogenesis.

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Metastatic cervical carcinoma to the thyroid gland: A rare diagnosis

Cited by 3 publications

References 3 publications

Thyroid metastasis from cervical carcinoma

Thyroid metastasis from cervical carcinoma

Squamous cell carcinoma of the uterine cervix metastasising to the thyroid gland: a case report

Squamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classification

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