Metastasizing eccrine porocarcinoma developing in a sebaceous nevus of Jadassohn. Report of a case

Sebaceous Carcinoma, Basal Cell Carcinoma, Trichoadenoma, Trichoblastoma, and Syringocystadenoma Papilliferum Arising within a Nevus Sebaceus

“…On the one hand, prophylactic excision may seem unnecessary, because malignant tumors arising within nevus sebaceus usually do not behave aggressively and because simple excision of the tumor usually effects a cure. [9][10][11][12] On the other hand, prophylactic excision seems warranted, because aggressive neoplasms arising within a nevus sebaceus can result in unnecessary morbidity or, rarely, death. 9,10,[12][13][14] The occurrence of multiple benign and malignant neoplasms in the nevus sebaceus of our patient suggests that prophylactic excision or at least close clinical surveillance for new growths is warranted.…”

“…[9][10][11][12] On the other hand, prophylactic excision seems warranted, because aggressive neoplasms arising within a nevus sebaceus can result in unnecessary morbidity or, rarely, death. 9,10,[12][13][14] The occurrence of multiple benign and malignant neoplasms in the nevus sebaceus of our patient suggests that prophylactic excision or at least close clinical surveillance for new growths is warranted. The three benign tumors arising within the nevus sebaceus of our patient included a trichoblastoma, a tumor of hair follicle origins, and syringocystadenoma papilliferum, a tumor of sweat gland origin, most likely apocrine.…”

Secondary neoplasms arising from nevus sebaceus: A retrospective study of 450 cases in Taiwan

“…Development of various secondary neoplasms from NS have been described. Some of the secondary neoplasms are malignant and can be aggressive . The timing and indication for prophylactic excision for NS has been a controversial issue because the risk of malignant transformation has not been consistent in the previous studies .…”

Tumors associated with nevus sebaceous

“…However Cribier et al [5], Kaddu et al [6], Munoz‐Pérez et al [4], and Jaqueti et al [2] showed that those lesions were mostly trichoblastomas misinterpreted as basal cell carcinomas. Other reported malignancies associated with NS are squamous cell carcinoma, sebaceous carcinoma, apocrine carcinoma, porocarcinoma and malignant melanoma [7–11]. Metastatic or locally aggressive carcinomas are very rare [10, 11].…”