Metastases From Squamous Cell Carcinomas of the Skin

Cutaneous Squamous-Cell Carcinoma

“…For those with metastatic disease, however, the long-term prognosis is extremely poor. 1,58 Ten-year survival rates are less than 20 percent for patients with regional lymphnode involvement and less than 10 percent for patients with distant metastases. If metastasis does occur, regional lymph nodes are involved in approximately 85 percent of cases; approximately 15 percent of cases involve distant sites, including the lungs, liver, brain, skin, and bone.…”

Utility of Sentinel Lymphadenectomy in the Management of Patients With High-Risk Cutaneous Squamous Cell Carcinoma

“…Effective control of cutaneous SCC requires an understanding of its variable clinical behavior and malignant potential. The majority of lesions can be easily treated with a low risk of recurrence and metastasis 2–4 . A smaller subset of tumors, however, should be considered high risk 2,5 .…”

“…When cutaneous SCC metastasizes, it does so in a predictable manner, usually involving only the regional lymph nodes 3,4,7,9,10 . Once clinically detectable nodal metastasis has occurred, the prognosis is poor, with reported 5‐year survival rates of approximately 26% 2,6,7,11–13 .…”

Utility of Sentinel Lymphadenectomy in the Management of Patients With High-Risk Cutaneous Squamous Cell Carcinoma

“…When cutaneous SCC metastasizes, it does so in a predictable manner, usually involving only the regional lymph nodes. 3,4,7,9,10 Once clinically detectable nodal metastasis has occurred, the prognosis is poor, with reported 5-year survival rates of approximately 26%. 2,6,7,[11][12][13] The dilemma therefore lies in the management of high-risk cutaneous SCCs with no clinical or radiologic evidence of metastatic disease or a clinical N0 status.…”