Metastability in Senescence

Naik, Shruti; Banerjee, Arpan; Bapi, Raju S.; Deco, Gustavo; Roy, Dipanjan

doi:10.1016/j.tics.2017.04.007

Cited by 68 publications

(98 citation statements)

References 90 publications

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“…Metastability, a measure of dynamic flexibility whereby the brain transitions through different states, was computed as the standard deviation of the Kuramoto order parameter (45,46). Higher metastability is a potential marker for cognitive and behavioural functioning (45,(47)(48)(49). Synchrony, a measure of general coherence (50), was computed as the mean of the Kuramoto order parameter.…”

Section: Global-brain Level Fcmentioning

confidence: 99%

Data-Driven Clustering Reveals a Link Between Symptoms and Functional Brain Connectivity in Depression

Maglanoc

Landrø

Jonassen

et al. 2019

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Section: Global-brain Level Fcmentioning

confidence: 99%

Data-Driven Clustering Reveals a Link Between Symptoms and Functional Brain Connectivity in Depression

Maglanoc

Landrø

Jonassen

et al. 2019

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…(Vasa et al, 2015). For a review of the complementary nature of global coherence and metastability, see (Deco et al 2017, Hellyer et al 2015, Vasa et al 2015. It is evident how spontaneous metastable brain dynamics would contribute to cognitive flexibility.…”

Section: An Example Of This Is a Recent Computational Study By Vasa Ementioning

confidence: 99%

“…We want to discuss these results in the light of two opposing theories of healthy aging. The method of neuro-compensation argues that age-related changes in brain dynamics suggest a compensatory mechanism by which function gets restored in response to structural decline (Naik et al 2017). In this regard, it is interesting to note that Alzheimer's disease and Traumatic brain injuries are associated with a reduction in global metastability (Córdova-Palomera et al, 2017;Hellyer et al, 2015).…”

Section: An Example Of This Is a Recent Computational Study By Vasa Ementioning

confidence: 99%

“…Theories such as HAROLD (Hemispheric asymmetry reduction in older adults), PASA (posterior to anterior shift with age) and CRUNCH (Compensation related utilization of neural circuit hypothesis) characterize ageing on the basis of topographical changes in activation patterns during task conditions. On the other hand theories like DECHA (default to executive coupling hypothesis with age) look at age associated changes as arising from impaired connectivity between specific functional modules in the brain (Naik et al 2017). The latter approach emphasises the network dimension, whereas, the former approach confines itself to tracking changes in gross patterns of activation contingent upon tasks.…”

Section: Theories Of Ageingmentioning

confidence: 99%

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Lifespan associated global patterns of coherent neural communication

Sahoo

Pathak

Deco

et al. 2018

Preprint

Self Cite

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AbstractHealthy ageing is accompanied by changes to spontaneous electromagnetic oscillations. At the macroscopic scale, previous studies have quantified the basic features, e.g., power and frequencies in rhythms of interest from the perspective of attention, perception, learning and memory. On the other hand, signatures and modes of neural communication have recently been argued to be identifiable from global measures applied on neuro-electromagnetic data such as global coherence that quantifies the degree of togetherness of distributed neural oscillations and metastability that parametrizes the transient dynamics of the network switching between successive stable states. Here, we demonstrate that global coherence and metastability can be informative measures to track healthy ageing dynamics over lifespan and together with the traditional spectral measures provides an attractive explanation of neuronal information processing. Finding normative patterns of brain rhythms in resting state MEG would naturally pave the way for tracking task relevant metrics that could crucially determine cognitive flexibility and performance. While previously reported observations of a reduction in peak alpha frequency and increased beta power in older adults are reflective of changes at individual sensors (during rest and task), global coherence and metastability truly pinpoint the underlying coordination dynamics over multiple brain areas across the entire lifespan. In addition to replication of the previous observations in a substantially larger lifespan cohort than what was previously reported, we also demonstrate, for the first time to the best of our knowledge, age related changes in coherence and metastability in signals over time scales of neuronal processing. Furthermore, we observed a marked frequency dependence in changes in global coordination dynamics, which, coupled with the long held view of specific frequency bands sub-serving different aspects of cognition, hints at differential functional processing roles for slower and faster brain dynamics.

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“…An interesting question to ask is how the formation of chimera states can be influenced by the loss of functionality of some of the constituent components of the system. In the case of the brain it could be the damage suffered by some of the neuronal components due to aging or disease 21 . For a model system of coupled oscillators this can be the loss of oscillatory behavior of some of the oscillators.…”

Section: Introductionmentioning

confidence: 99%

Amplitude mediated chimera states with active and inactive oscillators

Mukherjee

Sen

2018

Chaos: An Interdisciplinary Journal of Nonlinear Science

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The emergence and nature of amplitude mediated chimera states, spatio-temporal patterns of co-existing coherent and incoherent regions, are investigated for a globally coupled system of active and inactive Ginzburg-Landau oscillators. The existence domain of such states is found to shrink and shift in parametric space with the increase in the fraction of inactive oscillators. The role of inactive oscillators is found to be twofold-they get activated to form a separate region of coherent oscillations and, in addition, decrease the common collective frequency of the coherent regions by their presence. The dynamical origin of these effects is delineated through a bifurcation analysis of a reduced model system that is based on a mean field approximation. Our results may have practical implications for the robustness of such states in biological or physical systems where age related deterioration in the functionality of components can occur.

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Metastability in Senescence

Cited by 68 publications

References 90 publications

Data-Driven Clustering Reveals a Link Between Symptoms and Functional Brain Connectivity in Depression

Data-Driven Clustering Reveals a Link Between Symptoms and Functional Brain Connectivity in Depression

Lifespan associated global patterns of coherent neural communication

Amplitude mediated chimera states with active and inactive oscillators

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