Metals in the molluscan kidney: Uptake and subcellular distribution of 109Cd, 54Mn and 65Zn by the clam, Mercenaria mercenaria

Effects of heavy metals on Drosophila larvae and a metallothionein cDNA.

“…In agreement with several published reports (6)(7)(8)(9) we have detected copper within gut epithelium lysosomes by X-ray microanalysis. We further noticed that the highest copper concentrations are in dense intralysosomal inclusions (data not shown); similar mineralized concretions have been found in adult Musca domestic (8) and in mollusks (20). It seems likely that these lysosomal concretions within cuprophilic cells contain the fraction of insoluble copper while the soluble fraction is distributed between the bulk of proteins and metallothionein.…”

Effects of heavy metals on Drosophila larvae and a metallothionein cDNA.

“…In agreement with several published reports (6)(7)(8)(9) we have detected copper within gut epithelium lysosomes by X-ray microanalysis. We further noticed that the highest copper concentrations are in dense intralysosomal inclusions (data not shown); similar mineralized concretions have been found in adult Musca domestic (8) and in mollusks (20). It seems likely that these lysosomal concretions within cuprophilic cells contain the fraction of insoluble copper while the soluble fraction is distributed between the bulk of proteins and metallothionein.…”

Behavior of trace metals in Mytiius edulis during a reciprocal transplant field experiment

“…Concentric concretions and other granules rich in heavy elements have been found in the kidneys of several molluscs (Doyle et al, 1978;Carmichael et al, 1979Carmichael et al, , 1980. These bodies have been identified in membrane-bound vesi-cles that a r e associated with a n d considered t o b e f o r m e d b y lysosomes (George e t al., 1978; Lowe a n d Moore, 1979).…”

Effects of Heavy Metals on Drosophila Larvae and a Metallothionein cDNA

“…Although the synthesis of CBP starts soon after the initiation of cadmium treatment, it takes several hours for the protein to reach a level high enough to bind most (8) and in mollusks (20). It seems likely that these lysosomal concretions within cuprophilic cells contain the fraction of insoluble copper while the soluble fraction is distributed between the bulk of proteins and metallothionein.…”

Effects of heavy metals on Drosophila larvae and a metallothionein cDNA.

“…In agreement with several published reports (6)(7)(8)(9) we have detected copper within gut epithelium lysosomes by X-ray microanalysis. We further noticed that the highest copper concentrations are in dense intralysosomal inclusions (data not shown); similar mineralized concretions have been found in adult Musca domestic (8) and in mollusks (20). It seems likely that these lysosomal concretions within cuprophilic cells contain the fraction of insoluble copper while the soluble fraction is distributed between the bulk of proteins and metallothionein.…”

Behavior of trace metals in Mytiius edulis during a reciprocal transplant field experiment

“…Concentric concretions and other granules rich in heavy elements have been found in the kidneys of several molluscs (Doyle et al, 1978;Carmichael et al, 1979Carmichael et al, , 1980. These bodies have been identified in membrane-bound vesi-cles that a r e associated with a n d considered t o b e f o r m e d b y lysosomes (George e t al., 1978; Lowe a n d Moore, 1979).…”

Effects of Heavy Metals on Drosophila Larvae and a Metallothionein cDNA

“…Although the synthesis of CBP starts soon after the initiation of cadmium treatment, it takes several hours for the protein to reach a level high enough to bind most (8) and in mollusks (20). It seems likely that these lysosomal concretions within cuprophilic cells contain the fraction of insoluble copper while the soluble fraction is distributed between the bulk of proteins and metallothionein.…”

Effects of heavy metals on Drosophila larvae and a metallothionein cDNA.

“…In agreement with several published reports (6)(7)(8)(9) we have detected copper within gut epithelium lysosomes by X-ray microanalysis. We further noticed that the highest copper concentrations are in dense intralysosomal inclusions (data not shown); similar mineralized concretions have been found in adult Musca domestic (8) and in mollusks (20). It seems likely that these lysosomal concretions within cuprophilic cells contain the fraction of insoluble copper while the soluble fraction is distributed between the bulk of proteins and metallothionein.…”

Behavior of trace metals in Mytiius edulis during a reciprocal transplant field experiment

“…Concentric concretions and other granules rich in heavy elements have been found in the kidneys of several molluscs (Doyle et al, 1978;Carmichael et al, 1979Carmichael et al, , 1980. These bodies have been identified in membrane-bound vesi-cles that a r e associated with a n d considered t o b e f o r m e d b y lysosomes (George e t al., 1978; Lowe a n d Moore, 1979).…”

Effects of Heavy Metals on Drosophila Larvae and a Metallothionein cDNA

“…Although the synthesis of CBP starts soon after the initiation of cadmium treatment, it takes several hours for the protein to reach a level high enough to bind most (8) and in mollusks (20). It seems likely that these lysosomal concretions within cuprophilic cells contain the fraction of insoluble copper while the soluble fraction is distributed between the bulk of proteins and metallothionein.…”