Metal oxide nanoparticles as cross-linkers in polymeric hybrid hydrogels

Pasqui, Daniela; Atrei, A.; Giani, Gabriele; Cagna, Milena De; Barbucci, Rolando

doi:10.1016/j.matlet.2010.10.053

Cited by 57 publications

(39 citation statements)

References 20 publications

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“…However, these traditional approaches have many limitations, including the possible release of the NP from the hydrogel matrix into the external environment. One strategy to overcome these problems involves the use of NPs as hydrogel cross-linker agents [12,17].…”

Section: Open Accessmentioning

confidence: 99%

“…APTMS hydrolyzes in the presence of water and, in a subsequent reaction, the silanol groups condensate with the hydroxyl groups on the NPs' surface to form M-O-Si covalent bonds. This method introduces onto the NP surface the amino group essential to create an amide bond with the activated carboxylic group of CMC polymers [12,17]. , can be attributed to the vibrational modes involving the bridging oxygen atoms in Si-O-Si and Si-O bonds [18].…”

Section: Functionalized Nanoparticles (Np-nh 2 )mentioning

confidence: 99%

“…The strategy for the synthesis of CMC-NP involves the formation of amide bonds between the carboxylic groups of CMC and the amine groups of the functionalized NPs in the presence of EDC and NHS [12,17]. A schematic diagram of the reaction is shown in Figure 6.…”

Section: Hybrid Hydrogel (Cmc-np) Synthesismentioning

confidence: 99%

“…The NP functionalization reaction was carried out by means of the chemistry of silane molecules, according to the procedure already reported in literature [12,17]. Briefly, 5 mL of (3-aminopropyl)-trimethoxysilane (APTMS), corresponding to a molar ratio of 4.5 relative to the moles of the NPs, were added to a suspension containing 0.5 g of NPs in a 95/5% v/v ethanol/water mixture at pH 5.…”

Section: Functionalization Of the Cofe 2 O 4 Nps (Np-nh 2 )mentioning

confidence: 99%

“…The CMC hybrid hydrogel containing NP-NH 2 was prepared using a procedure already reported in the literature [12,17]. Briefly, 1 g of CMC was first dissolved in deionized water at a concentration of 1.5% w/v.…”

Section: Preparation Of the Hybrid Hydrogel (Cmc-np)mentioning

confidence: 99%

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Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields

Giani¹,

Fedi²,

Barbucci³

2012

Polymers

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Abstract:Novel hybrid magnetic hydrogels have demonstrated their influence in several areas, particularly in biomedical science where these innovative materials are showing interesting applications for controlled drug delivery. A hybrid hydrogel with CoFe 2 O 4 nanoparticles (NPs) as cross-linker agents of carboxymethylcellulose (CMC) polymer was obtained with the aim of testing it as a system for controlled drug release. The NPs were functionalized with (3-aminopropyl)-trimethoxysilane (APTMS) in order to introduce-NH 2 groups on the surface. Infrared spectroscopy, XPS and electrochemical analysis were performed to quantify the amino coating. The presence of magnetic nanoparticles makes the system suitable for an application with magnetic stimulus. Preliminary studies performed with alternating magnetic fields indicate a release of the drug-like molecules previously loaded in the matrix.

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Section: Open Accessmentioning

confidence: 99%

Section: Functionalized Nanoparticles (Np-nh 2 )mentioning

confidence: 99%

Section: Hybrid Hydrogel (Cmc-np) Synthesismentioning

confidence: 99%

Section: Functionalization Of the Cofe 2 O 4 Nps (Np-nh 2 )mentioning

confidence: 99%

Section: Preparation Of the Hybrid Hydrogel (Cmc-np)mentioning

confidence: 99%

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Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields

Giani¹,

Fedi²,

Barbucci³

2012

Polymers

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A Review of Design and Fabrication Methods for Nanoparticle Network Hydrogels for Biomedical, Environmental, and Industrial Applications

Campea

Majcher

Lofts

et al. 2021

Adv Funct Materials

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Nanoparticle network hydrogels (NNHs) in which nanoparticles are used as a key building block to build the gel network have attracted significant interest given their potential to leverage the favorable properties of both hydrogels (e.g., hydrophilicity, tunable pore sizes, mechanics, etc.) and a variety of different nanoparticles (e.g., high surface area, chemical activity, independently tunable porosity, mechanics) to create new functional materials. Herein, recent progress in the design and use of NNHs is comprehensively reviewed, with an emphasis on defining the typical gel morphologies/architectures that can be achieved with NNHs, the typical crosslinking approaches used to fabricate NNHs, the fundamental properties and functional benefits of NNHs, and the reported applications of NNHs in electronics (flexible electronics, sensors), environmental (sorbents, separations), agriculture, self‐cleaning‐materials, and biomedical (drug delivery, tissue engineering) applications. In particular, the way in which the NNH structure is applied to improve the performance of the hydrogel in each application is emphasized, with the aim to develop a set of principles that can be used to rationally design NNHs for future uses.

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Nanocomposite hydrogels for biomedical applications

Gaharwar

Peppas²,

Khademhosseini

2013

Biotech & Bioengineering

991

754

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Hydrogels mimic native tissue microenvironment due to their porous and hydrated molecular structure. An emerging approach to reinforce polymeric hydrogels and to include multiple functionalities focuses on incorporating nanoparticles within the hydrogel network. A wide range of nanoparticles, such as carbon-based, polymeric, ceramic, and metallic nanomaterials can be integrated within the hydrogel networks to obtain nanocomposites with superior properties and tailored functionality. Nanocomposite hydrogels can be engineered to possess superior physical, chemical, electrical, and biological properties. This review focuses on the most recent developments in the field of nanocomposite hydrogels with emphasis on biomedical and pharmaceutical applications. In particular, we discuss synthesis and fabrication of nanocomposite hydrogels, examine their current limitations and conclude with future directions in designing more advanced nanocomposite hydrogels for biomedical and biotechnological applications.

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Metal oxide nanoparticles as cross-linkers in polymeric hybrid hydrogels

Cited by 57 publications

References 20 publications

Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields

Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields

A Review of Design and Fabrication Methods for Nanoparticle Network Hydrogels for Biomedical, Environmental, and Industrial Applications

Nanocomposite hydrogels for biomedical applications

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