Metal-organic frameworks for simultaneous gene and small molecule delivery in vitro and in vivo

Ringaci, A.; Yaremenko, A. V.; Шевченко, К. Г.; Zvereva, Svetlana; Nikitin, Maxim P.

doi:10.1016/j.cej.2021.129386

Cited by 53 publications

(22 citation statements)

References 58 publications

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“…We also studied carefully the effect of different factors on the efficiency of a macrophage blockade in vivo induced by solid nanomaterials [147], and we demonstrated that RBC-hitchhiking can boost the delivery of nontargeted particles to the lungs up to the record of 120-fold [148]. As for other aspects of in vivo magneto-fection, there are several different strategies to improve existing nonviral vector systems, including the search for new hybrid magnetic materials [149], the search for or synthesis of biodegradable polymers with reduced toxicity, the addition of active targeting to target cells [150,151] to improve selectivity, and additional transport domains for efficient and targeted delivery. In all these fields, there is room for development.…”

Section: Discussionmentioning

confidence: 99%

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

et al. 2021

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Magnetic nanoparticles have been widely used in nanobiomedicine for diagnostics and the treatment of diseases, and as carriers for various drugs. The unique magnetic properties of “magnetic” drugs allow their delivery in a targeted tumor or tissue upon application of a magnetic field. The approach of combining magnetic drug targeting and gene delivery is called magnetofection, and it is very promising. This method is simple and efficient for the delivery of genetic material to cells using magnetic nanoparticles controlled by an external magnetic field. However, magnetofection in vivo has been studied insufficiently both for local and systemic routes of magnetic vector injection, and the relevant data available in the literature are often merely descriptive and contradictory. In this review, we collected and systematized the data on the efficiency of the local injections of magnetic nanoparticles that carry genetic information upon application of external magnetic fields. We also investigated the efficiency of magnetofection in vivo, depending on the structure and coverage of magnetic vectors. The perspectives of the development of the method were also considered.

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Section: Discussionmentioning

confidence: 99%

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

et al. 2021

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“…That causes rapid plasma clearance of the nanocarriers leading to short nanoparticle plasma half-life [102]. Therefore, it is necessary to study in detail the issues related to the factors that affect blood circulation [8,103], as well as elimination [104,105] of nanoparticles for successful applications of in vivo magnetofection, search for new hybrid delivering nanomaterials [106][107][108][109] or implementation of more efficient biochemical binding and targeting techniques [110][111][112][113][114][115][116]. However, we believe that the magnetofection technique can become a solid option for in vivo targeting combined with improved efficacy of gene delivery, potentially in combination with other physical techniques (electroporation, sonoporation) if appropriate magnetic fields can be generated and if an ideal coating of magnetic particles is found.…”

Section: Discussionmentioning

confidence: 99%

Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream

2021

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Nanoparticle-based technologies are rapidly expanding into many areas of biomedicine and molecular science. The unique ability of magnetic nanoparticles to respond to the magnetic field makes them especially attractive for a number of in vivo applications including magnetofection. The magnetofection principle consists of the accumulation and retention of magnetic nanoparticles carrying nucleic acids in the area of magnetic field application. The method is highly promising as a clinically efficient tool for gene delivery in vivo. However, the data on in vivo magnetofection are often only descriptive or poorly studied, insufficiently systematized, and sometimes even contradictory. Therefore, the aim of the review was to systematize and analyze the data that influence the in vivo magnetofection processes after the systemic injection of magnetic nanostructures. The main emphasis is placed on the structure and coating of the nanomagnetic vectors. The present problems and future trends of the method development are also considered.

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“…Nanomaterials have been extensively used for drug delivery applications [116][117][118][119]. If chemically functionalized CNMs, in particular, filled nanotubes, are used for drug delivery, they can greatly enhance the efficiency of the therapeutics.…”

Section: Drug Deliverymentioning

confidence: 99%

Applications of Pristine and Functionalized Carbon Nanotubes, Graphene, and Graphene Nanoribbons in Biomedicine

et al. 2021

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This review is dedicated to a comprehensive description of the latest achievements in the chemical functionalization routes and applications of carbon nanomaterials (CNMs), such as carbon nanotubes, graphene, and graphene nanoribbons. The review starts from the description of noncovalent and covalent exohedral modification approaches, as well as an endohedral functionalization method. After that, the methods to improve the functionalities of CNMs are highlighted. These methods include the functionalization for improving the hydrophilicity, biocompatibility, blood circulation time and tumor accumulation, and the cellular uptake and selectivity. The main part of this review includes the description of the applications of functionalized CNMs in bioimaging, drug delivery, and biosensors. Then, the toxicity studies of CNMs are highlighted. Finally, the further directions of the development of the field are presented.

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Metal-organic frameworks for simultaneous gene and small molecule delivery in vitro and in vivo

Cited by 53 publications

References 58 publications

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream

Applications of Pristine and Functionalized Carbon Nanotubes, Graphene, and Graphene Nanoribbons in Biomedicine

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