Metal-induced oxidative stress level in patients with fibromyalgia syndrome and its contribution to the severity of the disease: A correlational study

Abstract

BACKGROUND: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease characterised by widespread chronic musculoskeletal pain. Metal-induced oxidative stress contributes to the severity of FMS. AIMS: First, this study evaluated the association between plasma levels of toxic heavy metals and essential metals with oxidative stress (OS) markers. Second, the OS markers and metal contents were correlated with the disease severity by assessing the Fibromyalgia Impact Questioner Revised (FIQR) and tender points (TP). METHOD: A total of 105 FMS patients and 105 healthy controls of similar age and sex were recruited. OS parameter such as lipid peroxidation (LPO), protein carbonyl group (PCG), nitric oxide (NO) and essential metals such as zinc (Zn), magnesium (Mg), manganese (Mn), copper (Cu) and toxic heavy metals such as aluminium (Al), arsenic (As), lead (Pb) were estimated. RESULTS: Levels of LPO, PCG, NO (p< 0.001) and Cu, Mn, and Al (p< 0.001), were significantly higher, and Mg (p< 0.001) and Zn (p< 0.001) were significantly lower in patients compared to controls. A positive association was observed between OS parameters, FIQR and TP with Cu, Al and Mn. A significant negative association was observed between Zn and Mg with FIQR, TP and OS parameters. CONCLUSION: Heavy metals such as Al induce OS parameters and decrease the levels of essential trace elements such as Mg and Zn, which may be responsible for the severity of FMS.

Prevalence of specific micronutrient deficiencies in urban school going children and adolescence of India: A multicenter cross-sectional study

“…Analysis of blood samples was done at Department of Biochemistry, KGMU. Quantitative determination of zinc and selenium in the serum was done by Inductively Coupled Plasma-Optical Emission Spectrometer (ICP-OES, Optima 8000, Perkin Elmer, USA) [ 34 ]. The level of vitamin D, Vitamin B12 and folate were analyzed in serum by Chemiluminescent Microparticle Immunoassay (CMIA) technology with flexible assay protocol provided by kit ARCHITECT 25-OH VITAMIN D, ARCHITECT B12 and ARCHITECT Folate (Abbot Diagnostics, Iceland) respectively [ 35 – 37 ].…”

Oxidative Stress in Fibromyalgia: From Pathology to Treatment

“…Similar data were presented by La Rubia et al, Abdulnasser et al, and Shukla et al, who observed that serum copper, manganese, and aluminum concentration were significantly higher in fibromyalgia patients than in healthy controls. Moreover, the higher concentration of these metals correlated with high FIQR and manifested as increased tender points and pain sensation in FM subjects [ 32 , 63 , 80 ]. Thus, copper and ceruloplasmin may play a role in contributing to the oxidative stress pathogenesis of fibromyalgia.…”

Zinc in fibromyalgia patients: relationship with body mass index and sleep quality

“…Moreover, oxidative stress markers also showed negative correlation with zinc and magnesium. 25 In our country, significantly lower serum zinc and magnesium concentrations were determined in FM patients compared to the healthy controls, whereas no significant difference was found for serum selenium concentration. A significant correlation was demonstrated between zinc concentration and the number of tender points, suggesting that these elements might play a role in the pathogenesis of FM.…”