Metal based nanoparticles trigger the differential expression of key regulatory genes which regulate iron and zinc homeostasis mechanism in finger millet

Chandra, Ajay; Pandey, Dinesh; Tiwari, Apoorv; Gururani, Kavita; Agarwal, Aparna; Dhasmana, Anupam; Kumar, Anil

doi:10.1016/j.jcs.2021.103235

Cited by 16 publications

(10 citation statements)

References 22 publications

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“…The sequence analysis of identified chimeric ZHD proteins revealed wide variability in molecular weight, number of amino acids, GRAVY, aliphatic index, instability index, and isoelectric point (pI). The studied physicochemical properties might directly influence the stability of the chimeric protein ( Chandra et al., 2021 ). Stability variations could be one of the driving factors for reduced leaf lamina joint angle with erect and rolled leaf behavior of the ZHD proteins while accumulation in sub-cellular compartments (i.e., nucleus) of the plants ( Liu et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Cis- acting regulatory elements are a regulatory component of promoter regions of many genes that provide clues for stress responsiveness, light-responsiveness, hormonal responsiveness, growth and development, and other gene-specific expression patterns under specific environmental and growth conditions ( Yun et al., 2010 ; Xu F. et al, 2012 ; Abdullah et al., 2018 ; Chandra et al., 2021 ). As reported in earlier studies, we predicted many Cis -regulatory elements in TaZHD1 and TaZHD10 promoter regions.…”

Section: Discussionmentioning

confidence: 99%

“…Cis- acting regulatory elements like Sp1 and G-box play a specific role as light-responsive elements, whereas GC-motif is an enhancer-like element involved in anoxic specific inducibility of target genes ( Ezer et al., 2017 ; Liu et al., 2021 ). Besides zinc finger, the presence of numerous Cis -acting regulatory elements, including MYC (myelocytomatosis oncogene), CGTCA-motif, TGACG-motif, ABRE (ABA-responsive element), CCAAT-box, DRE core (dehydration-responsive element) and MYB (myeloblastosis oncogene) recognition site, suggesting the existence of multiple regulatory mechanisms in response to drought stress ( Singh and Laxmi, 2015 ; Baldoni et al., 2015 ; Khatun et al., 2017 ; Dong et al., 2019 ; Chandra et al., 2021 ; Liu et al., 2021 ), that resulted in leaf rolling in plants ( Dong et al., 2019 ). Additionally, the CCAAT-box contains MYBH1 binding sites that regulate various abiotic stresses and developmental processes ( Laloum et al., 2013 ).…”

Section: Discussionmentioning

confidence: 99%

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Leaf rolling in bread wheat (Triticum aestivum L.) is controlled by the upregulation of a pair of closely linked/duplicate zinc finger homeodomain class transcription factors during moisture stress conditions

et al. 2022

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Zinc finger-homeodomain (ZF-HDs) class IV transcriptional factors (TFs) is a plant-specific transcription factor and play a key role in stress responses, plant growth, development, and hormonal signaling. In this study, two new leaf rolling TFs genes, namely TaZHD1 and TaZHD10, were identified in wheat using comparative genomic analysis of the target region that carried a major QTL for leaf rolling identified through multi-environment phenotyping and high throughput genotyping of a RIL population. Structural and functional annotation of the candidate ZHD genes with its closest rice orthologs reflects the species-specific evolution and, undoubtedly, validates the notions of remote-distance homology concept. Meanwhile, the morphological analysis resulted in contrasting difference for leaf rolling in extreme RILs between parental lines HD2012 and NI5439 at booting and heading stages. Transcriptome-wide expression profiling revealed that TaZHD10 transcripts showed significantly higher expression levels than TaZHD1 in all leaf tissues upon drought stress. The relative expression of these genes was further validated by qRT-PCR analysis, which also showed consistent results across the studied genotypes at the booting and anthesis stage. The contrasting modulation of these genes under drought conditions and the available evidenced for its epigenetic behavior that might involve the regulation of metabolic and gene regulatory networks. Prediction of miRNAs resulted in five Tae-miRs that could be associated with RNAi mediated control of TaZHD1 and TaZHD10 putatively involved in the metabolic pathway controlling rolled leaf phenotype. Gene interaction network analysis indicated that TaZHD1 and TaZHD10 showed pleiotropic effects and might also involve other functions in wheat in addition to leaf rolling. Overall, the results increase our understanding of TaZHD genes and provide valuable information as robust candidate genes for future functional genomics research aiming for the breeding of wheat varieties tolerant to leaf rolling.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Leaf rolling in bread wheat (Triticum aestivum L.) is controlled by the upregulation of a pair of closely linked/duplicate zinc finger homeodomain class transcription factors during moisture stress conditions

et al. 2022

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“…181 Fe 3 O 4 and ZnO NPs triggered the differential expression of Zn and Fe transporters, especially the higher transcriptional regulation of EcFER1, EcIRT2, EcYSL2, EcZIP1 and EcZTP29, maintaining the homeostasis of Zn and Fe in finger millet. 182 The metal ions released by some MNPs at low doses can be absorbed by plant roots, providing trace mineral elements for plant growth and development. But at high doses, it will cause plant "toxicosis metallicus" and cause a series of physiological and biochemical damage, even death.…”

Section: Nutrient Absorptionmentioning

confidence: 99%

Interplay of metal-based nanoparticles with plant rhizosphere microenvironment: implications for nanosafety and nano-enabled sustainable agriculture

Wang

Zhang

Zhao

et al. 2023

Environ. Sci.: Nano

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“…Several iron transporters have been extensively studied in various plant models such as wheat, rice, maize and finger millet, etc. (Anuradha et al 2017;Boonyaves et al 2017;Chandra et al 2021). When the nanoparticle enters the cytoplasm, further cell-to-cell movement occurs with the help of plasmodesmata (Lin et al 2009;Geisler-Lee et al 2012;Zhai et al 2014).…”

Section: Mode Of Uptake and Translocationmentioning

confidence: 99%

Iron fortification of food crops through nanofertilisation

Chugh

Siddique

Solaiman

2022

Crop & Pasture Science

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Micronutrient deficiencies are a significant cause of malnutrition worldwide, particularly in developing countries, affecting nearly 1.8 billion people worldwide. Agriculture is the primary source of nutrients for humans, but the increasing population and reducing arable lands areas are putting the agricultural sector under pressure, particularly in developing and less developed countries, and calls for intensive farming to increase crop yield to overcome food and nutrients deficiency challenges. Iron is an essential microelement that plays a vital role in plant and human growth, and metabolism, but its deficiency is widely reported and affects nearly one-third of the world population. To combat micronutrient deficiency, crops must have improved nutritional qualities or be biofortified. Several biofortification programs with conventional breeding, biotechnological and agronomic approaches have been implemented with limited success in providing essential nutrients, especially in developing and under-developed countries. The use of nanofertilisers as agronomic biofortification method to increase yields and nutrients, micronutrient availability in soil and uptake in plant parts, and minimising the reliance on harmful chemical fertilisers is essential. Using nanoparticles as nanofertilisers is a promising approach for improving the sustainability of current agricultural practices and for the biofortification of food crop production with essential micronutrients, thus enhanced nutritional quality. This review evaluates the current use of iron nanofertilisers for biofortification in several food crops addressing critical knowledge gaps and challenges that must be addressed to optimise the sustainable application.

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Metal based nanoparticles trigger the differential expression of key regulatory genes which regulate iron and zinc homeostasis mechanism in finger millet

Cited by 16 publications

References 22 publications

Leaf rolling in bread wheat (Triticum aestivum L.) is controlled by the upregulation of a pair of closely linked/duplicate zinc finger homeodomain class transcription factors during moisture stress conditions

Leaf rolling in bread wheat (Triticum aestivum L.) is controlled by the upregulation of a pair of closely linked/duplicate zinc finger homeodomain class transcription factors during moisture stress conditions

Interplay of metal-based nanoparticles with plant rhizosphere microenvironment: implications for nanosafety and nano-enabled sustainable agriculture

Iron fortification of food crops through nanofertilisation

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