Metagenomics for Lipase

Quasi-opsonin conjugated lipase-sensitive micelles activate macrophages against facultative intracellular bacterial infection

“…22 It can act in a wide range of temperatures and pH, 23 making it more applicable as a stimulus for antibiotic release from the carrier. 24 Herein, biocompatible polycaprolactone (PCL), 25 a substrate of lipase, was selected as a responsive material to construct PEG-PCL copolymer, then conjugated with B-mLBP to self-assemble a quasi-opsonized chloramphenicol (Chl) loaded system (B-mLBP-M/Chl) to combat S.typhimurium bacteraemia. As illustrated in Fig.…”