Metachronous Advanced Neoplasia on Surveillance Colonoscopy in Patients With Young- vs Older-onset of Colorectal Cancer

Tjaden, Jamie M.; Muller, Charles; Wideroff, Gina; Ma, Karen; Satiya, Jinendra; Sussman, Daniel A.; Yen, Eugene F.; Kupfer, Sonia S.; Melson, Joshua

doi:10.1016/j.cgh.2019.07.034

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Of the included studies, 13 investigated risk factors for metachronous CRC [4,14,[19][20][21][22][23][24][25][26][27][28][29], and 9 for metachronous advanced neoplasia [30][31][32][33][34][35][36][37][38]. Characteristics of included studies are shown in Table 1 and Table 2.…”

Section: Resultsmentioning

confidence: 99%

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Risk factors for metachronous colorectal cancer and advanced neoplasia following primary colorectal cancer: A systematic review and meta-analysis

Zhang

Karahalios

Aung

et al. 2023

Preprint

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Background Identifying risk factors for metachronous colorectal cancer (CRC) and metachronous advanced neoplasia could be useful for guiding surveillance and cancer prevention. We conducted a systematic review and meta-analysis to investigate the risk factors for metachronous CRC and advanced neoplasia. Methods Searches were conducted in MEDLINE, Embase, Web of Science and Cochrane Central Registry of Controlled Trials. Random effects models were fitted to estimate the association between the investigated risk factors and metachronous CRC or advanced neoplasia. Results 22 articles were included in the systematic review. The risks of metachronous CRC or advanced neoplasia were higher if the first CRC was diagnosed in the presence of a synchronous advanced lesion (pooled risk ratio (RR) from 3 studies: 3.61, 95% confidence interval (CI): 1.44–9.05; and pooled RR from 8 studies: 2.77, 95% CI: 2.23–3.43, respectively). The risk of metachronous CRC was lower, but the risk of metachronous advanced neoplasia was higher if the first CRC was distal (compared with proximal) (pooled RR from 3 studies: 0.48, 95% CI: 0.23–0.98; and pooled RR from 2 studies: 2.99, 95% CI: 1.60–5.58 respectively). The risk of metachronous advanced neoplasia increased with age (pooled RR from 3 studies: 1.07 per year of age, 95% CI: 1.03–1.11). There was no evidence that any lifestyle risk factors studied were associated with the risk of metachronous CRC or advanced neoplasia. Conclusions Identified risk factors for metachronous CRC and advanced neoplasia might be useful to tailor the existing surveillance guidelines after the first CRC.

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Section: Resultsmentioning

confidence: 99%

“…All 22 studies were cohort studies. Seven studies were conducted in Europe [4, 21-23, 27, 35, 37], ten studies in Asia [14, 26, 28-31, 33, 34, 36, 38], four studies in USA [19,24,25,32] and one across multiple countries [20].…”

Section: Resultsmentioning

confidence: 99%

Risk factors for metachronous colorectal cancer and advanced neoplasia following primary colorectal cancer: A systematic review and meta-analysis

Zhang

Karahalios

Aung

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…All 22 studies were cohort studies. Seven studies were conducted in Europe [ 4 , 22 – 24 , 28 , 36 , 38 ], ten studies in Asia [ 15 , 27 , 29 – 32 , 34 , 35 , 37 , 39 ], four studies in USA [ 20 , 25 , 26 , 33 ] and one across multiple countries [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Risk factors for metachronous colorectal cancer and advanced neoplasia following primary colorectal cancer: a systematic review and meta-analysis

Zhang,

Karahalios,

Aung

et al. 2023

BMC Gastroenterol

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Background Identifying risk factors for metachronous colorectal cancer (CRC) and metachronous advanced neoplasia could be useful for guiding surveillance. We conducted a systematic review and meta-analysis to investigate risk factors for metachronous CRC and advanced neoplasia. Methods Searches were conducted in MEDLINE, Embase, Web of Science and Cochrane Central Registry of Controlled Trials for articles (searching period: 1945 to Feburary, 2021) that reported the results of an association between any factor and metachronous advanced neoplasia or metachronous CRC. There were no restrictions on the publication date or language. Random effects models were fitted to estimate the combined association between the risk factors and metachronous CRC or advanced neoplasia. The Risk of Bias In Non-Randomised Studies of Interventions tool (ROBINS-I) was used to assess the risk of bias of included studies. Results In total, 22 observational studies with 625,208 participants were included in the systematic review and meta-analysis. Of these, 13 studies investigated risk factors for metachronous CRC and 9 for advanced neoplasia. The risks of metachronous CRC or advanced neoplasia were higher if the first CRC was diagnosed in the presence of a synchronous advanced lesion (pooled risk ratio (RR) from 3 studies: 3.61, 95% confidence interval (CI): 1.44–9.05; and pooled RR from 8 studies: 2.77, 95% CI: 2.23–3.43, respectively). The risk of metachronous CRC was lower, but the risk of metachronous advanced neoplasia was higher if the first CRC was distal (compared with proximal) (pooled RR from 3 studies: 0.48, 95% CI: 0.23–0.98; and pooled RR from 2 studies: 2.99, 95% CI: 1.60–5.58 respectively). The risk of metachronous advanced neoplasia increased with age (pooled RR from 3 studies: 1.07 per year of age, 95% CI: 1.03–1.11). There was no evidence that any lifestyle risk factors studied were associated with the risk of metachronous CRC or advanced neoplasia. Conclusions The identified risk factors for metachronous CRC and advanced neoplasia might be useful to tailor the existing surveillance guidelines after the first CRC. There were potential limitations due to possible misclassification of the outcome, confounding and risk of bias, and the findings cannot be generalised to high-risk genetic syndrome cases.

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Early-onset Colorectal Cancer Patients Do Not Require Shorter Intervals for Post-surgical Surveillance Colonoscopy

Mendelsohn,

Hahn,

Palmaira

et al. 2024

Clinical Gastroenterology and Hepatology

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Metachronous Advanced Neoplasia on Surveillance Colonoscopy in Patients With Young- vs Older-onset of Colorectal Cancer

Cited by 4 publications

References 2 publications

Risk factors for metachronous colorectal cancer and advanced neoplasia following primary colorectal cancer: A systematic review and meta-analysis

Risk factors for metachronous colorectal cancer and advanced neoplasia following primary colorectal cancer: A systematic review and meta-analysis

Risk factors for metachronous colorectal cancer and advanced neoplasia following primary colorectal cancer: a systematic review and meta-analysis

Early-onset Colorectal Cancer Patients Do Not Require Shorter Intervals for Post-surgical Surveillance Colonoscopy

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