Metachromins A and B, novel antineoplastic sesquiterpenoids from the Okinawan sponge Hippospongia cf. metachromia

The Brazilian marine biodiversity represents a unique, yet underexplored resource of biologically active compounds. This review provides an analysis of the development of marine natural products chemistry in Brazil within the period comprised between 2004 and 2017. Emphasis is directed towards marine invertebrate and marine microorganisms metabolites, including isolation, structure analysis, biosynthesis, bioactivities and total synthesis. An overview of the research on marine natural products by Brazilian researchers is also discussed, as well as perspectives for the development of the chemistry of marine natural products in Brazil.

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“…A convergent synthesis of metachromin A (309), previously isolated from the sponge Hippospongia metachromia, 112 has been completed (Scheme 11).…”

Section: Aromatic Derivativesmentioning

confidence: 99%

Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards

Ióca¹,

Nicácio²,

Berlinck³

2018

J. Braz. Chem. Soc.

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“…All thorectandrols, including the parent compound of the group palauolide [21] and palauolol [22] have been assayed for antiproliferative activity against human tumor cell lines and found to be active against all but one of the cell lines assayed [23] . Sponges of the genus Hippospongia are a source of various sesterterpenoids, which possess a broad spectrum of bioactivities, including isocitrate lyase (ICL) inhibitory [24] , cytotoxic [25][26][27][28][29][30] , antispasmodic [31] , and antibacterial [32] activities. Recently Chang et al, 2012 [32] isolated two novel sesterterpenoids from Hippospongia sp.…”

Section: Sesterterpenoids (C 25 )mentioning

confidence: 99%

Novel natural product discovery from obligate symbiotic organisms of marine sponges

Monaco

Quinlan

2018

J Nat Agents Mol Ther

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A rich source for the discovery of novel, pharmacologically active natural products have been the terrestrial plants and microbes, accounting for about 85% of the approved natural products in pharmaceutical use, and about 60% of approved pharmaceuticals and new drug applications submission annually. Discovery in the marine environment has lagged due to the difficulty of exploration in this ecological niche. Such exploration began in the 1950's, after technological advances such as scuba diving which allowed collection of marine organisms, primarily to a depth of about 15 m, which was the limit of that technology. Natural products from filter feeding marine invertebrates and in particular, sponges, have proven to be a rich source of structurally unique pharmacologically active compounds, with over 16,000 molecules isolated thus far and a continuing pace of discovery at hundreds of novel bioactive molecules per year. All classes of pharmaceuticals have been represented in this discovery process, including antiprotozoals, pesticides, TGF-beta inhibitors, cationic channel blockers, anticancer, cytotoxic, antiviral, anti-inflammatory and antibacterial compounds. Important biosynthetic pathways found in sponges which give rise to these compounds include the terpenoid, fatty acid, polyketoid, quinone reductase, alkaloid, isoprenoid, and non-ribosomal protein synthase pathways as summarized in this article.

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“…Sponges of the genus Hippospongia are a source of various sesterterpenoids, which possess a broad spectrum of bioactivities, including isocitrate lyase (ICL) inhibitory [29], cytotoxic [30][31][32][33][34][35], antispasmodic [36], and antibacterial [37] activities. Recently Chang et al, (2012) isolated two novel sesterterpenoids from Hippospongia sp.…”

Section: Sesterterpenoids (C 25 )mentioning

confidence: 99%

Novel Natural Product Discovery from Marine Sponges and their Obligate Symbiotic Organisms

Monaco

Quinlan

2014

Preprint

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Discovery of novel natural products is an accepted method for the elucidation of pharmacologically active molecules and drug leads. Best known sources for such discovery have been terrestrial plants and microbes, accounting for about 85% of the approved natural products in pharmaceutical use (1), and about 60% of approved pharmaceuticals and new drug applications annually (2). Discovery in the marine environment has lagged due to the difficulty of exploration in this ecological niche. Exploration began in earnest in the 1950's, after technological advances such as scuba diving allowed collection of marine organisms, primarily at a depth to about 15m. Natural products from filter feeding marine invertebrates and in particular, sponges, have proven to be a rich source of structurally unique pharmacologically active compounds, with over 16,000 molecules isolated thus far (3, 1) and a continuing pace of discovery at hundreds of novel bioactive molecules per year. All classes of pharmaceuticals have been represented in this discovery process, including antiprotazoals, pesticides, TGF-beta inhibitors, cationic channel blockers, anticancer, cytotoxic, antiviral, anti-inflammatory and antibacterial compounds. Important biosynthetic pathways found in sponges which give rise to these compounds include the terpenoid (4), fatty acid, polyketoid, quinone reductase, alkaloid, isoprenoid (5), and non-ribosomal protein synthase pathways.

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Metachromins A and B, novel antineoplastic sesquiterpenoids from the Okinawan sponge Hippospongia cf. metachromia

Cited by 54 publications

References 1 publication

Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards

Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards

Novel natural product discovery from obligate symbiotic organisms of marine sponges

Novel Natural Product Discovery from Marine Sponges and their Obligate Symbiotic Organisms

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