Metabotropic Glutamate Receptors in Amygdala Functions

Ferraguti, Francesco

doi:10.1007/978-3-319-56170-7_13

Cited by 2 publications

(1 citation statement)

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“…The cochlear regions show an intense expression of group I mGluRs and a region-specific expression of the other two groups [108]. While many comprehensive reviews have discussed these aspects [109][110][111][112][113], this review will focus on mGluRs in AD cognitive functions.…”

Section: Other Regulatory Functionsmentioning

confidence: 99%

Metabotropic Glutamate Receptors in Alzheimer’s Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future

Srivastav

Das

Yao

et al. 2020

JAD

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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the presence of neuritic plaques and neurofibrillary tangles. The impaired synaptic plasticity and dendritic loss at the synaptic level is an early event associated with the AD pathogenesis. The abnormal accumulation of soluble oligomeric amyloid-β (Aβ), the major toxic component in amyloid plaques, is viewed to trigger synaptic dysfunctions through binding to several presynaptic and postsynaptic partners and thus to disrupt synaptic transmission. Over time, the abnormalities in neural transmission will result in cognitive deficits, which are commonly manifested as memory loss in AD patients. Synaptic plasticity is regulated through glutamate transmission, which is mediated by various glutamate receptors. Here we review recent progresses in the study of metabotropic glutamate receptors (mGluRs) in AD cognition. We will discuss the role of mGluRs in synaptic plasticity and their modulation as a possible strategy for AD cognitive improvement.

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