Metabolomic profiling of early inactive hepatic alveolar and cystic echinococcosis

Bai, Zhenzhong; Ma, Xiaohua; Yan, Rong; Li, Wen; Zhang, Yifan; Ren, Yanming; Liu, Shou

doi:10.1016/j.actatropica.2023.106875

Cited by 1 publication

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 13 Also, none of the metabolites in serum was found to be statistically significant to differentiate between the cases and controls, however, in the study by Lin et al, a significant elevation of glutamate, histidine, and lactate was seen in serum samples of CE cases while Bai et al in their study reported a significant decrease of glutamate in serum samples of CE cases. 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

Proton Nuclear Magnetic Resonance (1H NMR) Metabolomics Study in Serum, Urine, and Cystic Fluid for Differentiating Fertility and Staging of Intra-abdominal Hydatid Cyst in Adults

Sen,

Pandey,

Agarwal

et al. 2024

Euroasian Journal of Hepato-Gastroenterology

View full text Add to dashboard Cite

A bstract Background Cystic echinococcosis (CE) is a parasitic zoonosis caused by the tapeworm Echinococcus granulosus. Over the past few years, a lot of research has been done on liver illnesses using metabolomics techniques to identify biomarkers which could identify the diseases in its early stages. The present study was done to explore biomarkers in serum, urine, and cystic fluid which would help in differentiating, staging, and assessing fertility of intra-abdominal hydatid cyst by using proton nuclear magnetic resonance ( 1 H NMR) metabolomics. Materials and methods In the study, 28 subjects (16 cases and 12 controls) were enrolled. Staging of hydatid cysts was performed using ultrasonography. In patients complying with case and control definition, blood, urine, and cystic fluid were collected for complete blood count, urine culture, Echinococcus IgG enzyme-linked immunosorbent assay (ELISA), and metabolomic analysis. The 17, 15, and 11 metabolites in serum, urine, and cystic fluid samples were quantified, respectively, to differentiate between case and control group. Results In this study, we observed that there was a significant downregulation of succinate metabolite in urine samples of cases, down-regulation of five metabolites (isoleucine, valine, histidine, tyrosine and formate) and upregulation of alanine in cystic fluid of cases. Conclusion Current study demonstrates that metabolomics can be used non-invasively for rapid diagnosis of CE. This is one of the very few studies, which used 1 H NMR spectroscopy, to analyze the profile of metabolites in serum, urine, and cystic fluid in cases of CE and controls. How to cite this article Raj N, Pandey A, Roy R, et al . Proton Nuclear Magnetic Resonance (1H NMR) Metabolomics Study in Serum, Urine, and Cystic Fluid for Differentiating Fertility and Staging of Intra-abdominal Hydatid Cyst in Adults. Euroasian J Hepato-Gastroenterol 2024;14(1):30–34.

show abstract

Section: Discussionmentioning

confidence: 99%