Metabolomic analysis shows dysregulation in amino acid and NAD+ metabolism in palmitate treated hepatocytes and plasma of non-alcoholic fatty liver disease spectrum

Aggarwal, Savera; Yadav, Vipin K.; Maiwall, Rakhi; Rastogi, Archana; Pamecha, Viniyendra; Bedi, Onkar; Maras, Jaswinder Singh; Trehanpati, Nirupma; Ramakrishna, Gayatri

doi:10.1016/j.bbrc.2022.12.078

Cited by 7 publications

(1 citation statement)

References 29 publications

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“…Tyrosine metabolite 3-(4-hydroxyphenyl) lactate has been found to be associated with liver steatosis and fibrosis [ 88 ]. Palmitic acid-treated hepatocyte cell lines PH5CH8 and HepG2 showed typical features of steatosis, and differential changes in tyrosine and phenylalanine pathways, fatty acid metabolism, and bile acids [ 89 ]. MAFLD microbiota facilitated phenylalanine production in the MAFLD mouse model [ 90 ].…”

Section: Icrobial Metabolites On Metabolic-associated Fatty Liver Dis...mentioning

confidence: 99%

Roles of gut microbes in metabolic-associated fatty liver disease

Chen

2023

Tzu Chi Medical Journal

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Metabolic-associated fatty liver disease (MAFLD) is the most common chronic liver disease. Gut dysbiosis is considered a significant contributing factor in disease development. Increased intestinal permeability can be induced by gut dysbiosis, followed by the entry of lipopolysaccharide into circulation to reach peripheral tissue and result in chronic inflammation. We reviewed how microbial metabolites push host physiology toward MAFLD, including short-chain fatty acids (SCFAs), bile acids, and tryptophan metabolites. The effects of SCFAs are generally reported as anti-inflammatory and can improve intestinal barrier function and restore gut microbiota. Gut microbes can influence intestinal barrier function through SCFAs produced by fermentative bacteria, especially butyrate and propionate producers. This is achieved through the activation of free fatty acid sensing receptors. Bile is directly involved in lipid absorption. Gut microbes can alter bile acid composition by bile salt hydrolase-producing bacteria and bacterial hydroxysteroid dehydrogenase-producing bacteria. These bile acids can affect host physiology by activating farnesoid X receptor Takeda G protein-coupled receptor 5. Gut microbes can also induce MAFLD-associated symptoms by producing tryptophan metabolites kynurenine, serotonin, and indole-3-propionate. A summary of bacterial genera involved in SCFAs production, bile acid transformation, and tryptophan metabolism is provided. Many bacteria have demonstrated efficacy in alleviating MAFLD in animal models and are potential therapeutic candidates for MAFLD.

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Section: Icrobial Metabolites On Metabolic-associated Fatty Liver Dis...mentioning

confidence: 99%