Metabolites of the Marine Fungus Aspergillus candidus KMM 4676 Associated with a Kuril Colonial Ascidian

Yurchenko, Anton N.; Ivanets, Elena V; Smetanina, O. F.; Пивкин, М. В.; Dyshlovoi, S. A.; Amsberg, Gunhild von; Afiyatullov, Sh. Sh.

doi:10.1007/s10600-017-2108-y

Cited by 15 publications

(11 citation statements)

References 12 publications

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“…The chemical composition of extract of an ascidian-derived fungus Aspergillus sp. KMM 4676 was reported earlier [ 29 , 30 ]. p -Terphenyl polyketides, candidusin A ( 4 ) and 4″-dehydroxycandidusin A ( 5 ), were major metabolites of this fungus.…”

Section: Resultsmentioning

confidence: 83%

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson’s Disease Models

et al. 2018

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A new melatonin analogue 6-hydroxy-N-acetyl-β-oxotryptamine (1) was isolated from the marine-derived fungus Penicillium sp. KMM 4672. It is the second case of melatonin-related compounds isolation from microfilamentous fungi. The neuroprotective activities of this metabolite, as well as 3-methylorsellinic acid (2) and 8-methoxy-3,5-dimethylisochroman-6-ol (3) from Penicillium sp. KMM 4672, candidusin A (4) and 4″-dehydroxycandidusin A (5) from Aspergillus sp. KMM 4676, and diketopiperazine mactanamide (6) from Aspergillus flocculosus, were investigated in the 6-hydroxydopamine (6-OHDA)- and paraquat (PQ)-induced Parkinson’s disease (PD) cell models. All of them protected Neuro2a cells against the damaging influence of 6-OHDA to varying degrees. This effect may be realized via a reactive oxygen species (ROS) scavenging pathway. The new melatonin analogue more effectively protected Neuro2A cells against the 6-OHDA-induced neuronal death, in comparison with melatonin, as well as against the PQ-induced neurotoxicity. Dehydroxylation at C-3″ and C-4″ significantly increased free radical scavenging and neuroprotective activity of candidusin-related p-terphenyl polyketides in both the 6-OHDA- and PQ-induced PD models.

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Section: Resultsmentioning

confidence: 83%

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson’s Disease Models

et al. 2018

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“…Fungi from marine environment are the second major class of ascidian-associated microorganisms, producers of secondary metabolites with an increased antimicrobial potential with respect to those derived from terrestrial fungi [155]. The production of several ascidian-derived bioactive compounds has been ascribed to Aspergillus sp., as demonstrated by the chemical analysis of marine fungal isolates from ascidians [156,157]. The symbiotic association between A. niger and the orange tunicate Aplidium sp.…”

Section: The Role Of Fungi In the Biosynthesis Of Antimicrobial Compomentioning

confidence: 95%

The Ascidian-Derived Metabolites with Antimicrobial Properties

2020

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Among the sub-phylum of Tunicate, ascidians represent the most abundant class of marine invertebrates, with 3000 species by heterogeneous habitat, that is, from shallow water to deep sea, already reported. The chemistry of these sessile filter-feeding organisms is an attractive reservoir of varied and peculiar bioactive compounds. Most secondary metabolites isolated from ascidians stand out for their potential as putative therapeutic agents in the treatment of several illnesses like microbial infections. In this review, we present and discuss the antibacterial activity shown by the main groups of ascidian-derived products, such as sulfur-containing compounds, meroterpenes, alkaloids, peptides, furanones, and their derivatives. Moreover, the direct evidence of a symbiotic association between marine ascidians and microorganisms shed light on the real producers of many extremely potent marine natural compounds. Hence, we also report the antibacterial potential, joined to antifungal and antiviral activity, of metabolites isolated from ascidian-associate microorganisms by culture-dependent methods.

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“…Similarly, candidusin A ( 11 ) and 4-dehydroxycandidusin A ( 12 ) from Aspergillus sp. KMM 4676, and diketopiperazine mactanamide ( 13 ) from Aspergillus flocculosus , can protect Neuro2A cells from the toxicity effects of 6-OHDA via scavenging ROS (Figure 3) [29,30,31]. These results suggested that such compounds may be used to develop anti-PD leads.…”

Section: Potential Candidates From Marine-derived Compounds For Thmentioning

confidence: 99%

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

2019

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Parkinson’s disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons, leading to the motor dysfunctions of patients. Although the etiology of PD is still unclear, the death of dopaminergic neurons during PD progress was revealed to be associated with the abnormal aggregation of α-synuclein, the elevation of oxidative stress, the dysfunction of mitochondrial functions, and the increase of neuroinflammation. However, current anti-PD therapies could only produce symptom-relieving effects, because they could not provide neuroprotective effects, stop or delay the degeneration of dopaminergic neurons. Marine-derived natural compounds, with their novel chemical structures and unique biological activities, may provide anti-PD neuroprotective effects. In this study, we have summarized anti-PD marine-derived natural products which have shown pharmacological activities by acting on various PD targets, such as α-synuclein, monoamine oxidase B, and reactive oxygen species. Moreover, marine-derived natural compounds currently evaluated in the clinical trials for the treatment of PD are also discussed.

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Metabolites of the Marine Fungus Aspergillus candidus KMM 4676 Associated with a Kuril Colonial Ascidian

Cited by 15 publications

References 12 publications

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson’s Disease Models

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson’s Disease Models

The Ascidian-Derived Metabolites with Antimicrobial Properties

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

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