Metabolites from the Marine Isolate of the Fungus Aspergillus versicolor KMM 4644

Isolation, Structural Characterization and Antidiabetic Activity of New Diketopiperazine Alkaloids from Mangrove Endophytic Fungus Aspergillus sp. 16-5c

“…In addition to the isolation of the above new compounds, ten known analogues including brevianamide Q ( 7 ) [ 22 ], brevianamide R ( 8 ) [ 22 ], brevianamide K ( 9 ) [ 21 ], brevianamide W ( 10 ) [ 18 ], N -Prenyl-cyclo- l -tryptophyl- l -proline ( 11 ) [ 23 ], brevianamide F ( 12 ) [ 24 ], epi-deoxybrevianamide E ( 13 ) [ 25 ], cyclo-(tryptophyl-phenylalanyl) ( 14 ) [ 26 ], brevianamide M ( 15 ) [ 21 ] and brevianamide N ( 16 ) [ 21 ] were isolated and identified from this fungus. Their structures were determined by comparing their NMR and MS data with the reported in literatures.…”

“…In order to find potent antidiabetic natural products, all the compounds (1-16) were screened for the enzyme inhibitory activities against α-glucosidase and PTP1B (Table 3). Compared with the positive control acarbose (408 μM), all of the tested compounds, except compounds 5, 12, and 13, showed good to mod- In addition to the isolation of the above new compounds, ten known analogues including brevianamide Q (7) [22], brevianamide R (8) [22], brevianamide K (9) [21], brevianamide W (10) [18], N-Prenyl-cyclo-L-tryptophyl-L-proline (11) [23], brevianamide F (12) [24], epi-deoxybrevianamide E (13) [25], cyclo-(tryptophyl-phenylalanyl) ( 14) [26], brevianamide M (15) [21] and brevianamide N (16) [21] were isolated and identified from this fungus. Their structures were determined by comparing their NMR and MS data with the reported in literatures.…”

New Metabolites from a Marine Sediment-Derived Fungus, Aspergillus carneus

“…The cytotoxic activity against ascitic murine Ehrlich carcinoma cells and antiradical activity to DPPH were tested for all isolated compounds 1-10. Ethyl averantin (6) The influence of aversin on Hsp70 expression in Ehrlich carcinoma cells was evaluated. Up to a concentration 100 μM aversin did not effect Hsp70 expression in this cell type.…”

“…The most intensive peak in the EI mass spectrum (m/z 256) corresponds to the ion [M-C 7 H 8 ] + , which is typical for diorcinolic diphenyl esters [2]. The 1 H NMR data analysis indicated the presence of five aromatic (δ H 6 1). The coupling constants of H-2 (δ H 6.36, t, J = 2.1 Hz), H-2' (δ H 6.25, d, J = 2.3 Hz) and H-6' (δ H 6.38, d, J = 2.6 Hz) indicated a meta-location of protons H-2, H-4 and H-6; H-2' and H-6'.…”

“…Compound 2 was named decumbenone D. 3). The HMBC correlations (Figure 6, Table 3 In addition to compounds 1-5 the well-known fungal polyketides ethyl averantin (6) [7], 6,8-di-O-methyl averufin (7) [8], sterigmatocystin (8) [7b], aversin (9) [9] and radiclonic acid (10) [10] were isolated from this strain of A. carneus (Figure 7). Radiclonic acid was not previously reported for any Aspergillus species.…”