Metabolic Tumor Burden Predicts for Disease Progression and Death in Lung Cancer

Lee, Percy; Weerasuriya, Dilani K.; Lavori, Philip W.; Quon, Andrew; Hara, Wendy; Maxim, Peter G.; Le, Quynh‐Thu; Wakelee, Heather A.; Donington, Jessica S.; Graves, Edward E.; Loo, Billy W.

doi:10.1016/j.ijrobp.2007.04.036

Cited by 177 publications

(172 citation statements)

References 15 publications

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“…Peak SUV (SUV Peak ), defined as the average SUV within a small region of interest (1.2 cm of diameter) around the SUV Max , is a more robust alternative to SUV Max . However, SUV Peak may not be representative of nonhomogeneous overall tumor uptake, and the ideal size of the ROI is still unclear (Lee et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Castelli

Bari

Depeursinge

et al. 2016

Critical Reviews in Oncology/Hematology

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International audience18 F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) allows to quantify the metabolic activity of a tumor (glycolysis) and has become a reference tool in oncology for the staging, restaging, radiotherapy planning and monitoring response in many cancers. Quantitative analyses have been introduced in order to overcome some of the limits of the visual methods, allowing an easier and more objective comparison of the inter- and intra-patients variations. The aims of this review were to report available evidences on the clinical value of quantitative PET/CT parameters in HNC. Forty-five studies, for a total of 2928 patients, were analyzed. Most of the data available dealt with the intensity of the metabolism, calculated from the Standard Uptake Value (SUV). Metabolic Tumor Volume (MTV) was well correlated with overall survival and disease free survival, with a higher predictive value than the maximum SUV. Spatial distribution of metabolism and textural analyses seems promising

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Section: Discussionmentioning

confidence: 99%

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Castelli

Bari

Depeursinge

et al. 2016

Critical Reviews in Oncology/Hematology

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“…A metaanalysis reported that the Ki-67 labeling index has prognostic significance in patients with NSCLC and that a high index suggests a poor prognosis [24]. A correlation between cell metabolic activity as determined by 18 F-FDG PET/CT SUV and cell proliferative activity as determined by the Ki-67 expression level has been suggested by some studies on NSCLC [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…We chose the most intense point on each malignant lesion and drew the lesion boundaries using SUV-based contouring software. A fixed 50 % of local maximum intensity was used as the threshold intensity value, and this was deemed reasonable from previous studies [16][17][18]. When the automated software included not only malignant lesions but also background activity, we manually removed the background boundaries by reviewing the background CT findings.…”

Section: Image Interpretation and Quantitationmentioning

confidence: 99%

“…Ten patients who were treated with chemotherapy or radiotherapy before the 18 F-FDG PET/CT scan, five who had brain metastases, five who had another primary malignancy, and four whose 18 F-FDG PET/CT scan imaging data were insufficient were also excluded. Finally, 94 patients were enrolled in this study.…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…Positron emission tomography/computed tomography (PET/CT) using the tracer 18 F-fluorodeoxyglucose ( 18 F-FDG) has emerged as an essential oncological imaging tool for diagnosing, staging, restaging, and determining treatment response [8]. The standardized uptake value (SUV), which is the most popular semiquantitative parameter to objectify PET/CT data, reflects the glucose metabolic rate and is used to characterize tumor metabolism in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Park

Lee

Rhee

et al. 2016

Nucl Med Mol Imaging

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Purpose The aim of this study was to evaluate the relationship between semiquantitative parameters on 18 F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC). Methods Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent 18 F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on 18 F-FDG PET/ CT images. The protein expression of Ki-67 was examined by immunohistochemical staining. Results Significant correlations were found between the MTVsum and Ki-67 labeling index (r=0.254, p=0.014) and the TLGtotal and Ki-67 labeling index (r=0.239, p=0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r=0.116, p=0.264) and the avgSUVmean and Ki-67 labeling index (r=0.031, p=0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p=0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p= 0.526 and 0.729, respectively). Conclusion In conclusion, the volume-based parameters of 18 F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by 18 F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells.

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Prognostic value of metabolic tumor volume as measured by fluorine‐18‐fluorodeoxyglucose positron emission tomography/computed tomography in nasopharyngeal carcinoma

Yoon

Lee

Hong

et al. 2014

Int Forum Allergy Rhinol

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Metabolic Tumor Burden Predicts for Disease Progression and Death in Lung Cancer

Cited by 177 publications

References 15 publications

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Prognostic value of metabolic tumor volume as measured by fluorine‐18‐fluorodeoxyglucose positron emission tomography/computed tomography in nasopharyngeal carcinoma

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