Metabolic syndrome and skin: Psoriasis and beyond

Padhi, Tanmay; Garima,

doi:10.4103/0019-5154.113950

Cited by 57 publications

(58 citation statements)

References 85 publications

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“…SKO mice displayed significantly increased skin inflammation, evident from increases in expression of inflammatory genes related to psoriasis, tissue damage, and the wound-healing process (36). Although psoriasis is generally associated with obesity (53)(54)(55), the observation of increased markers of wound healing in the skin of SKO mice is potentially significant in explaining the increased energy metabolism in these animals. Wound healing is an extremely energy-intensive process (56 -58).…”

Section: Inflammation and Wound Healing In Skin Of Scd1-deficient Micementioning

confidence: 99%

Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

Sampath

Ntambi

2014

Journal of Biological Chemistry

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The skin is the single largest organ in humans, serving as a major barrier to infection, water loss, and abrasion. The functional diversity of skin requires the synthesis of large amounts of lipids, such as triglycerides, wax esters, squalene, ceramides, free cholesterol, free fatty acids, and cholesterol and retinyl esters. Some of these lipids are used as cell membrane components, signaling molecules, and a source of energy. An important class of lipid metabolism enzymes expressed in skin is the ⌬ 9 -desaturases, which catalyze the synthesis in ⌬ 9 -monounsaturated lipids, primarily oleoyl-CoA (18:1n-9) and palmitoylCoA (16:1n-7), the major monounsaturated fatty acids in cutaneous lipids. Mice with a deletion of the ⌬ 9 -desaturase-1 isoform (SCD1) either globally (Scd1 ؊/؊ ) or specifically in the skin (skin-specific Scd1-knockout; SKO) present with marked changes in cutaneous lipids and skin integrity. Interestingly, these mice also exhibit increased whole body energy expenditure, protection against diet-induced adiposity, hepatic steatosis, and glucose intolerance. The increased energy expenditure in skin-specific Scd1-knockout (SKO) mice is a surprising phenotype, as it links cutaneous lipid homeostasis with whole body energy balance. This minireview summarizes the role of skin SCD1 in regulating skin integrity and whole body energy homeostasis and offers a discussion of potential pathways that may connect these seemingly disparate phenotypes.

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Section: Inflammation and Wound Healing In Skin Of Scd1-deficient Micementioning

confidence: 99%

Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

Sampath

Ntambi

2014

Journal of Biological Chemistry

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“…Metabolic syndrome is found to be associated with Lichen planus and other dermatological conditions such as psoriasis, skin tags, androgenetic alopecia, acanthosisnigricans, systemic lupus erythematosus. 9 The International Diabetes Federation criteria to define metabolic syndrome has been used in this study.…”

Section: Introductionmentioning

confidence: 99%

“…The levels of these adipocytokines have been shown to be elevated in many dermatological diseases. 10 Shi-Sheng Zhou has illustrated about another factor namely Oxidative stress is a condition of oxidant/antioxidant imbalance in which the net amount of reactive oxygen species (ROS) exceeds the antioxidant capacity of the body. Xenobiotics is one of the major sources of ROS.…”

Section: Introductionmentioning

confidence: 99%

“…It has been proposed that any derangement in the elimination of ROS through sebum will increase levels of circulating lipids and cholesterol, thus increasing the risk of dyslipidemia and Metabolic syndrome. 9,11 The proposed immunological defect in endocrine dysfunction causing diabetes mellitus may also contribute to development of lichen planus.…”

Section: Introductionmentioning

confidence: 99%

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A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

2017

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Background: Lichen planus is an autoimmune, inflammatory papulosquamous disease affecting skin and mucous membrane with a possible association with the parameters of metabolic syndrome.Methods: We carried out a hospital based case control study among patients attending DVL OPD during a period of 1.5 years (January 2015 - May 2016). Study population included 40 cases of LP and 80 age and sex matched controls. Relevant history, clinical examination and blood investigations were done. Diagnosis of MS was made based on IDF criteria.Results: There was no significant association between metabolic syndrome and lichen planus (p=0.292). Although there was higher prevalence of hypertension (47.5% vs. 27.5%, p=0.029), triglyceride level (25% vs. 10%, p=0.030) and low HDLC levels (65% vs. 45%, p=0.039). We could not establish significant association between FBS and waist circumference with LP.Conclusions: Though metabolic syndrome was not significantly associated with LP, its components such as hypertension, triglycerides and low HDLC levels were significantly associated with LP as per the study. Therefore patients with LP need to be screened to rule out each of these parameters to avoid later complications.

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“…Cytokines like TNF-a, IL-6, intracellular adhesion molecule-1 play a key role in pathogenesis of psoriasis as well as MetS. 6 In recent past many studies have been conducted worldwide to evaluate the prevalence of metabolic syndrome in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic syndrome in psoriasis vulgaris: a cross sectional study from a tertiary care hospital of South-East Rajasthan

et al. 2016

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Background: Psoriasis, a common skin disorder is now considered as systemic inflammatory disease. Its chronic inflammatory state is thought to predispose patients to metabolic syndrome (MetS), which is a significant predictor of cardiovascular events. The objective of the study is to investigate the prevalence of metabolic syndrome in psoriatic patients with only cutaneous involvement and to evaluate the correlation between presence of MetS and psoriasis severityMethods: We performed hospital based, cross-sectional study on 100 adult patients with psoriasis vulgaris and equi-numbered age and sex matched controls. MetS was diagnosed by revised National Cholesterol Education Program’s Adult Panel III criteria.Results: A higher prevalence of metabolic syndrome was found in psoriasis patients as compared to controls [28 (28%) vs 9 (9%), P value=0.0005].Impaired fasting glucose level, hypertension, hypertriglyceridemia and abdominal obesity were more prevalent in psoriasis group. No statistically significant difference was found between prevalence of low levels of HDL and presence of metabolic syndrome. Presence of metabolic syndrome was not associated with severity and duration of psoriasis. Female patients with psoriasis were more frequently having metabolic syndrome.Conclusions: Prevalence of metabolic syndrome is higher in patients with psoriasis irrespective of its duration and severity. This stresses on the need of regular evaluation for the presence of MetS or any of its components in psoriasis patients so as to allow early detection and management.

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Metabolic syndrome and skin: Psoriasis and beyond

Cited by 57 publications

References 85 publications

Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

Prevalence of metabolic syndrome in psoriasis vulgaris: a cross sectional study from a tertiary care hospital of South-East Rajasthan

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