Metabolic syndrome and psoriasis: a study in 97 patients

Ferdinando, Lana; Fukumoto, Paula Kaori; Sanches, Sarah; Fabricio, L; Skare, Thelma Larocca

doi:10.1590/1806-9282.64.04.368

Cited by 20 publications

(33 citation statements)

References 30 publications

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“…[4][5][6]8 However, our results in Japanese psoriatic patients are rather different from those in Western countries: higher intake of fish/shellfish and pulses, and lower intake of meat compared with controls, though the Japanese patients showed higher BMI compared with controls, similar to Western patients. 7 The higher BMI and lower meat intake were independently associated with psoriasis, as analyzed by logistic regression. Both vitamin B 12 and vitamin D are rich in fish/shellfish, and thus the higher intake of these vitamins in the Japanese patients may be attributable to higher fish/shellfish intake.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies have revealed that psoriatic patients show higher body mass indices (BMI), and higher intake of fat and lower intake of fish or vegetables, compared with the reference groups. [4][5][6][7][8] The obesity and dietary habits above may be related to the development of skin lesions and high frequency of comorbidities, diabetes mellitus, dyslipidemia and cardiovascular diseases in psoriatic patients. 1,7 Obesity is a pro-inflammatory state, and visceral fat-derived adipokines like leptin or visfatin induce the production of psoriasis-promoting antimicrobial peptides, human b-defensin-2/3 or chemokines, CXCL8/10, CCL20 in epidermal keratinocytes, and link metabolic syndromes to psoriasis.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7][8] The obesity and dietary habits above may be related to the development of skin lesions and high frequency of comorbidities, diabetes mellitus, dyslipidemia and cardiovascular diseases in psoriatic patients. 1,7 Obesity is a pro-inflammatory state, and visceral fat-derived adipokines like leptin or visfatin induce the production of psoriasis-promoting antimicrobial peptides, human b-defensin-2/3 or chemokines, CXCL8/10, CCL20 in epidermal keratinocytes, and link metabolic syndromes to psoriasis. [9][10][11] Saturated fatty acid (SFA), rich in meat or butter, exacerbates psoriasis by promoting Th1/Th17 differentiation through activation of dendritic cells.…”

Section: Introductionmentioning

confidence: 99%

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Dietary habits in Japanese patients with psoriasis and psoriatic arthritis: Low intake of meat in psoriasis and high intake of vitamin A in psoriatic arthritis

Yamashita

Morita

Ito

et al. 2019

The Journal of Dermatology

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Psoriasis is characterized by T‐helper 17 cell‐dominant abnormal immunity, and hyperproliferation and abnormal differentiation of epidermal keratinocytes. Some patients are associated with arthritis. Dietary habits can modulate the pathogenesis of psoriasis. Previous studies in Western countries showed higher body mass indices, higher intake of fat and lower intake of fish or vegetables in psoriatic patients compared with the reference groups. We evaluated dietary habits in adult Japanese psoriatic patients, using a validated brief‐type self‐administered dietary history questionnaire, and compared the results to those of age‐ and sex‐matched healthy controls. The results in psoriatic patients with arthritis were compared with those in the patients without. Japanese psoriatic patients showed higher body mass indices, higher intake of fish/shellfish, pulses, sugar/sweeteners, vitamin B12 and vitamin D, and lower intake of meat, compared with those of healthy controls. The logistic regression analysis showed that psoriasis was associated with high body mass index and low intake of meat. The intake of confection in patients with high Psoriasis Area and Severity Index was higher than that in those with low index. The intake of β‐carotene, vitamin A and green/yellow vegetables in psoriatic patients with arthritis were higher than those in the patients without. The dietary habits in Japanese psoriatic patients are rather different from those in Western patients. This is the first study showing the differences in dietary habits between psoriatic patients with arthritis and those without. Further studies should elucidate the relationships of these results with skin and joint lesions in psoriatic patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary habits in Japanese patients with psoriasis and psoriatic arthritis: Low intake of meat in psoriasis and high intake of vitamin A in psoriatic arthritis

Yamashita

Morita

Ito

et al. 2019

The Journal of Dermatology

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“…Metabolic syndrome is a conglomerate of other diseases, defined generally to include several conditions that might include obesity, hypertension, and glucose intolerance. 20 Choudhary et al surveyed 63 studies and found the occurrence of metabolic syndrome in psoriasis patients to be as high as 50% as compared to 15-25% among the general population. 20 Another study found the rate to be 30%.…”

Section: Metabolic Syndromementioning

confidence: 99%

“…20 Choudhary et al surveyed 63 studies and found the occurrence of metabolic syndrome in psoriasis patients to be as high as 50% as compared to 15-25% among the general population. 20 Another study found the rate to be 30%. 14 According to Hajiebrahimi et al, metabolic syndrome has a prevalence of 50% in psoriasis patients.…”

Section: Metabolic Syndromementioning

confidence: 99%

Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis

Vebman¹,

Choy²,

Yao³

2020

J of Skin

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Introduction:-Psoriasis is a common disease that is linked with several other diseases. Our goals were to analyze and present literature on prevalence of various psoriatic comorbidities, and provide an estimate of what percent of psoriasis patients might have or develop Myocardial/cardiovascular/heart disease, stroke, diabetes, obesity, hypertension, or metabolic syndrome.Method:-To collect the results, we searched PubMed to identify papers that studied the frequency of the most common comorbidities of psoriasis. We used about 20. The search terms used were the particular comorbidity (or synonyms) and psoriasis. Papers were selected where the prevalence data were listed by percentages of the studied population. Prevalence data from each paper were collected and charted, and then compared. We did not use data that concerned Psoriatic Arthritis. We also recorded outliers, where frequencies did not fit with the other data found.Results:-Results for prevalence of myocardial/cardiovascular/heart disease were mixed, varying by age and severity of disease. There are few papers on prevalence of stroke, but our review suggests risk of stroke increases with severity of psoriasis. The prevalence of diabetes was largely between 10% and 20%. Obesity’s prevalence was mostly between 15% and 30%, while hypertension hovered around 30%, and metabolic syndrome prevalence was mostly between 27% and 50%.Conclusions:-There are many comorbidities of psoriasis. The complex interaction between cutaneous inflammation and heart disease, stroke, diabetes, hypertension and metabolic syndrome raises many questions about cause and effect or simple association.

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Inhibition of vascular endothelial growth factor‐A downregulates angiogenesis in psoriasis: A pilot study

Luengas‐Martinez

Ismail

Paus

et al. 2023

Skin Health and Disease

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BackgroundVascular Endothelial Growth Factor (VEGF)‐A‐mediated angiogenesis participates in the pathogenesis of psoriasis, thus inviting the hypothesis that anti‐VEGF‐A therapy could be beneficial in psoriasis. While anti‐angiogenic agents are used in oncology and ophthalmology, these therapeutic strategies remain unexplored for the management of psoriasis.ObjectiveOur objective was to investigate ex vivo how VEGF‐A blockade impacts blood vessels, epidermis and immune cells in organ‐cultured plaque and non‐lesional skin from patients with psoriasis.MethodsSkin biopsies from patients with psoriasis (n = 6; plaque and non‐lesional skin) and healthy controls (n = 6) were incubated with anti‐VEGF‐A monoclonal antibody (bevacizumab, Avastin®) or a human IgG1 isotype control for 72‐h in serum‐free organ culture. CD31/LYVE‐1, Ki‐67, and mast cell tryptase expression were assessed by quantitative immunohistomorphometry. VEGF‐A levels in plasma, PBMCs and skin culture supernatants were measured.ResultsInhibition of VEGF‐A blocked all free VEGF‐A ex vivo, reduced blood vessel area and the number of blood vessel endothelial cells in plaques of psoriasis (*p < 0.05). The treatment effect correlated significantly with levels of VEGF‐A in organ culture supernatants (r = 0.94; *p < 0.05) from plaque skin and with plasma levels of VEGF‐A from patients with psoriasis (r = 0.943; *p = 0.017).ConclusionsThese ex vivo data are the first studies to objectively investigate the potential of VEGF‐A inhibition as a novel adjuvant treatment strategy for psoriasis. Taken together, our data encourage further investigation by clinical trial to explore whether downregulating pathological angiogenesis has clinical utility, especially in patients with severe psoriasis or those with elevated levels of VEGF‐A in plasma and/or skin.

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Metabolic syndrome and psoriasis: a study in 97 patients

Abstract: In our psoriasis sample, MS prevalence is high and the items that deserve more attention are central obesity, low HDL, hypertension and smoking habits. In the psoriasis group, MS was associated independently with older age and less scalp involvement.

Cited by 20 publications

References 30 publications

Dietary habits in Japanese patients with psoriasis and psoriatic arthritis: Low intake of meat in psoriasis and high intake of vitamin A in psoriatic arthritis

Dietary habits in Japanese patients with psoriasis and psoriatic arthritis: Low intake of meat in psoriasis and high intake of vitamin A in psoriatic arthritis

Review of the Prevalence of Cardiovascular and Metabolic Comorbidities of Psoriasis

Inhibition of vascular endothelial growth factor‐A downregulates angiogenesis in psoriasis: A pilot study

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