Metabolic syndrome among HIV infected patients: A comparative cross sectional study in northwestern Nigeria

Muhammad, Fakhraddeen; Gezawa, Ibrahim; Uloko, Andrew; Yakasai, Ahmad M.; Habib, Abdulrazaq G.; Iliyasu, Garba

doi:10.1016/j.dsx.2017.03.046

Cited by 13 publications

(16 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Duro et al, HIV patients with MS had increased levels of C-reactive protein and interleukin-6 [21]. HIVrelated metabolic disturbances were more prevalent in female gender in our studies [6,9,15,19,20,30], old age was also an independent risk factor in some of the studies [6,12,14,15,19,20,30,31], and according to some studies, high BMI was a risk factor by itself [6,12,14,16,28].…”

Section: Discussionsupporting

confidence: 58%

“…Insulin resistance identified by homeostatic model assessment for insulin resistance (HOMA-IR) was prevalent in 79.3% of the ART-exposed patients compared to the 25.0% ART-naive group (p = 0.008). A particular class of ART or more extended periods of ART-exposure was not significantly associated with insulin resistance [14].…”

Section: Dysglycemiamentioning

confidence: 76%

“…HIV infection is one of the most common diseases in the world; in 2018, there were about 37.9 million people who suffered from this condition, of whom 24.7 million were able to access ART according to UNAIDS [1]. ART has been a great improvement for the survival of these patients [2], but this therapy is also associated with some adverse metabolic effects as well [12][13][14]. HIV itself may be related to metabolic effects as well [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…It is also known that MS increases cardiovascular disease (CVD) risk, and it is associated with insulin resistance, prothrombotic state, and proinflammatory state [4]. risk while HIV was not a big risk factor itself [12][13][14][15][16][17][18]; another group of studies proposed that HIV and ART increase the risk together [19][20][21]. At the other end of the spectrum, some studies propose combined ART may have good effects on HIV(+) patients who also meet the criteria for MS [22].…”

Section: Introductionmentioning

confidence: 99%

“…There is also some evidence about the hepatitis C virus (HCV), boosting the risk of these abnormalities caused by HIV/ART [29]. Older age [6,12,14,15,19,20,30,31], high BMI [6,14,16,28] and female gender [6,9,15,19,20,30] are also among the factors, which independently increases the risk of MS in patients with HIV/on ART. Table 1 contains the baseline BMI values of ART-exposed and ART-naive patients in some of the articles.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

HIV, Antiretroviral Therapy and Metabolic Alterations: A Review

Ergin¹,

Inga²,

Maung³

et al. 2020

Cureus

View full text Add to dashboard Cite

The introduction of antiretroviral therapy (ART) has caused some metabolic problems to people who suffer from HIV. ART probably is not the sole reason for these metabolic disorders. Most likely, HIV itself affects the metabolism as well. We conducted research to find the prevalence of the different types of metabolic disorders among HIV(+) patients. Female gender, high BMI, and older age are among the risk factors for the occurrence of metabolic disorders. Regarding dyslipidemia, hypertriglyceridemia and low high-density lipoproteins (HDLs) are the most common types of dyslipidemia in the studies we included. Protease inhibitors (PIs) are widely known as the most common class of antiretroviral drugs that cause metabolic disorders, and some studies in our review also demonstrated this knowledge. In our review, we concluded that HIV and ART concurrently alter the metabolism, but further research is required about this substantial topic.

show abstract