Alfredo Caro-Maldonado, Ruoning Wang, Amanda G. Nichols, Masayuki Kuraoka, Sandra Milasta, Lillian D. Sun, Amanda L. Gavin, E. Dale Abel, Garnett Kelsoe, Douglas R. Green, Jeffrey C. Rathmell
B cell activation leads to proliferation and antibody production that can protect from pathogens or promote autoimmunity. Regulation of cell metabolism is essential to support the demands of lymphocyte growth and effector function and may regulate tolerance. Here, we tested the regulation and role of glucose uptake and metabolism in the proliferation and antibody production of control, anergic, and autoimmune-prone B cells. Control B cells had a balanced increase in lactate production and oxygen consu…
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