Metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy

Wang, Shan; Fu, Jialei; Hao, Huifeng; Jiao, Yanna; Li, Pingping; Han, Shuyan

doi:10.1016/j.phrs.2021.105728

Cited by 95 publications

(61 citation statements)

References 114 publications

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“…CHM has a polypharmacological effect naturally based on the “multi-components, multi-targets and multi-pathways” principle ( Guo et al, 2020 ; Wang et al, 2021 ). Based on target molecules, biological function, and bioactive compounds, current developments in network pharmacology establish an intricate interaction network that matches the natural characteristics of CHM and provides the detailed action mechanism of CHM against CI/RI at the molecular level with a systematic viewpoint.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury

et al. 2022

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Cerebral ischemic reperfusion injury (CI/RI) is a critical factor that leads to a poor prognosis in patients with ischemic stroke. It is an extremely complicated pathological process that is clinically characterized by high rates of disability and mortality. Current available treatments for CI/RI, including mechanical and drug therapies, are often accompanied by significant side effects. Therefore, it is necessary to discovery new strategies for treating CI/RI. Many studies confirm that Chinese herbal medicine (CHM) was used as a potential drug for treatment of CI/RI with the advantages of abundant resources, good efficacy, and few side effects. In this paper, we investigate the latest drug discoveries and advancements on CI/RI, make an overview of relevant CHM, and systematically summarize the pathophysiology of CI/RI. In addition, the protective effect and mechanism of related CHM, which includes extraction of single CHM and CHM formulation and preparation, are discussed. Moreover, an outline of the limitations of CHM and the challenges we faced are also presented. This review will be helpful for researchers further propelling the advancement of drugs and supplying more knowledge to support the application of previous discoveries in clinical drug applications against CI/RI.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury

et al. 2022

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“…Studies have also shown that TCM can treat cardiovascular disease by protecting mitochondrial function [ 84 ]. Furthermore, metabolic reprogramming in TCM treatment of hypertension has received increasing attention [ 85 ], and metabolic reprogramming by TCM is also important for effective cancer therapy [ 86 ].…”

Section: Discussionmentioning

confidence: 99%

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Zhang

Wang

Shi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To develop a putative microRNA (miRNA) and messenger RNA (mRNA) regulatory network of Danggui Buxue decoction’s (DGBXD) amelioration of idiopathic pulmonary fibrosis (IPF). Methods. The Gene Expression Omnibus (GEO) database was used to identify differentially expressed miRNAs (DE-miRNAs) and differentially expressed mRNAs (DE-mRNAs). Using miRNet, the predicted target genes of identified DE-miRNAs were estimated, and then the target genes of DE-miRNAs in IPF were comprehensively examined. The Enrichr database was used to conduct functional enrichment and pathway enrichment. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was employed to obtain the target genes of DGBXD as well as active compounds. A putative miRNA-mRNA regulatory network of DGBXD acting on IPF was developed by intersecting the target genes of DGBXD with the DE-miRNA target genes in IPF. A bleomycin-induced mouse model was established and used to perform histopathology as well as real-time quantitative polymerase chain reaction (qRT-PCR) analyses of some miRNA-mRNA pairs. Results. Fourteen upmodulated DE-miRNAs and six downmodulated DE-miRNAs were screened. The downstream target genes of upmodulated and downmodulated DE-miRNAs were predicted. Subsequently, 1160 upmodulated DE-mRNAs and 1427 downmodulated DE-mRNAs were identified. Then, target genes of DE-miRNAs comprising 49 downmodulated and 53 upmodulated target genes were further screened to perform functional enrichment and pathway enrichment analyses. Subsequently, 196 target genes of DGBXD were obtained from TCMSP, with six downregulated target genes and six upregulated target genes of DGBXD acting on IPF being identified. A promising miRNA-mRNA regulatory network of DGBXD acting on IPF was developed in this study. Moreover, mir-493 together with its target gene Olr1 and mir-338 together with Hif1a were further validated by qRT-PCR. Conclusion. This study proposed detailed possible processes of miRNA-mRNA modulatory axis in IPF and constructed a prospective IPF-related miRNA-mRNA modulatory network with the aim of alleviating IPF with DGBXD.

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“…Moreover, blocking the TGF-β1/smad2 pathway with SB431542 reversed cleaved caspase-3 expression, intracellular ROS accumulation, and apoptosis of A549 cells. Scutellarin is a flavonoid isolated from the traditional Chinese medicine Erigeron breviscapus, which displays activity against cancer cells [17,18]. Cao et al [19] reported that scutellarin plays a role in inhibiting proliferation and promoting apoptosis in A549 cells.…”

Section: Discussionmentioning

confidence: 99%

Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-β1/smad2/ROS/caspase-3 pathway

Zhang

Chen

et al. 2021

Open Life Sciences

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Scutellarin plays an anti-tumor role in A549 lung cancer cells, but the underlying mechanism is unclear. In this study, scutellarin was used to treat A549 cells for 12, 24, and 48 h, followed by the addition of Tempo, a selective scavenger of mitochondrial reactive oxygen species (ROS) and SB431542, a transforming growth factor (TGF)-β1 receptor inhibitor. A dihydroethidium fluorescence probe was used to measure the intracellular ROS level, Cell Counting Kit-8 (CCK-8) was used to detect cell viability, and flow cytometry was performed to examine apoptosis. Western blots were used to detect the total protein level of TGF-β1, p-smad2, and cleaved caspase-3 in A549 cells. The results showed that scutellarin significantly inhibited cell viability and increased apoptosis. Scutellarin also promoted intracellular ROS production, TGF-β1/smad2 signaling pathway activation, and cleaved caspase-3 expression, which was partly reversed by Tempo. Moreover, scutellarin-induced intracellular ROS production and cleaved caspase-3 expression were inhibited by blocking the TGF-β1/smad2 pathway with SB431542. In conclusion, scutellarin promoted apoptosis and intracellular ROS accumulation, which could be abrogated by Tempo and SB431542 treatment in A549 cells. Our study indicated that scutellarin induced A549 cell apoptosis via the TGF-β1/smad2/ROS/caspase-3 pathway.

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Metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy

Cited by 95 publications

References 114 publications

Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury

Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-β1/smad2/ROS/caspase-3 pathway

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