2015
DOI: 10.18632/aging.100801
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Abstract: The cause of Alzheimer's disease is incompletely defined, and no truly effective therapy exists. However, multiple studies have implicated metabolic abnormalities such as insulin resistance, hormonal deficiencies, and hyperhomocysteinemia. Optimizing metabolic parameters in a comprehensive way has yielded cognitive improvement, both in symptomatic and asymptomatic individuals. Therefore, expanding the standard laboratory evaluation in patients with dementia may be revealing. Here I report that metabolic profil… Show more

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Cited by 47 publications
(53 citation statements)
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References 19 publications
(22 reference statements)
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“…Our findings correlate with other similar studies (21). Level of CRP in our study did not correlate significantly with global cognitive function unlike previous findings (22)(23)(24)(25). Our study showed that elevated PTH levels and severity of secondary hyperparathyroidism statistically significantly correlates with space and time orientation disorders.…”
Section: Discussionsupporting
confidence: 79%
“…Our findings correlate with other similar studies (21). Level of CRP in our study did not correlate significantly with global cognitive function unlike previous findings (22)(23)(24)(25). Our study showed that elevated PTH levels and severity of secondary hyperparathyroidism statistically significantly correlates with space and time orientation disorders.…”
Section: Discussionsupporting
confidence: 79%
“…There is a growing consensus that the most effective treatments will intervene early in disease progression and halt disease pathophysiological processes prior to conversion to LOAD 2 . In addition, there is increasing recognition that LOAD may in fact be a spectrum of related diseases that have similar clinical and neuropathological manifestations 3,4 . Devising successful therapeutic strategies will likely require targeting potentially diverse early-stage disease processes that occur prior to a high burden of neuropathology or cognitive impairment.…”
Section: Introductionmentioning
confidence: 99%
“…inflammatory, noninflammatory, and atypical), and that the type of each patient can be determined by profiling a set of biomarkers dominant in each type (e.g. APOE type, homocysteine, hs-CRP, IL-6, TNF-α, HbA1C, insulin, progesterone, estradiol, cortisol, vitamin D, zinc, heavy metal, mycotoxin) [92]. Factors with prominent effects in the Sgo1 −/+ model are being investigated, and will be determined with further time-course study focusing on these biomarkers and proposed facilitators.…”
Section: Late-onset Accumulation Of Amyloid-beta In Sgo1 Brainmentioning
confidence: 99%