2021
DOI: 10.3389/fmed.2021.631600
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Abstract: Epidemiological data clearly indicate a link between hepatitis C virus (HCV) and altered glucose homeostasis.Objective: To evaluate the response of treatment with direct antiviral agents (DAAs) on metabolic variables of patients with hepatitis C.Methods: Observational, cross-sectional study in a sample of patients with hepatitis C starting therapy with DAAs followed on the hepatology division of Federal University of Rio de Janeiro State. Data were collected in two stages: before the start of therapy and betwe… Show more

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Cited by 6 publications
(3 citation statements)
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References 54 publications
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“…Furthermore, these kinds of changes in lipid metabolism were reported by other recent studies where an increase in total cholesterol and LDL-cholesterol were found; however, the authors couldn’t find significant changes in triglyceride levels [ 34 , 35 ]. In a similar study which involved a reduced number of patients (97 individuals with HCV), Estefan et al found a significant increase in the level of triglycerides that appeared at the post-SVR evaluation (between 12 to 52 weeks) of the metabolic profile [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, these kinds of changes in lipid metabolism were reported by other recent studies where an increase in total cholesterol and LDL-cholesterol were found; however, the authors couldn’t find significant changes in triglyceride levels [ 34 , 35 ]. In a similar study which involved a reduced number of patients (97 individuals with HCV), Estefan et al found a significant increase in the level of triglycerides that appeared at the post-SVR evaluation (between 12 to 52 weeks) of the metabolic profile [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…eram diabéticos e 19,3% eram obesos (Estefan et al, 2021). Em diversos estudos no mundo foi demonstrada a alta prevalência de resistência insulínica, DM2, síndrome metabólica e obesidade em pacientes com hepatite C crônica (Shaheen et al, 2007;Moucari et al, 2008;Rouabhia et al, 2010;Mostafa et al, 2010;Van der Poorten et al, 2010).…”
Section: Doenças Metabólicas E Prevalência Nos Pacientesunclassified
“…Consequently, further evidence from long-term follow-up studies is still required to determine if successful eradication of HCV can help to ameliorate IR and improve glycemic control and clinical outcomes in patients with established DM2[ 33 , 34 ].…”
Section: Irmentioning
confidence: 99%