Metabolic disposition in rats of regular and enzymatically depolymerized sodium carboxymethylcellulose

Re‐evaluation of celluloses E 460(i), E 460(ii), E 461, E 462, E 463, E 464, E 465, E 466, E 468 and E 469 as food additives

“…The absorption and excretion of NaCMC was examined in rats (Bär et al., ). The 14 C label was in the two carbon atoms of the carboxymethyl group and the specific radioactivity was 0.27 μCi/mg.…”

“…As reported above, a comparative disposition study was carried out with 14 C‐labelled sodium CMC and enzymatically hydrolysed sodium CMC in adult Wistar rats (8 animals/sex; age not stated) (Bär et al., ). The enzymatically hydrolysed sodium CMC was recovered from the GI tract with an unchanged molecular weight, whereas the sodium CMC was reduced in molecular size.…”

“…The absorption and excretion of partially enzyme‐hydrolysed 14 C‐labelled enzymatically hydrolysed carboxy methyl cellulose was compared in rats to those of CMC in the above described study (Bär et al., ). Following the same experimental protocol, most of the radioactivity (89–99% of the dose) was excreted within 48 h after dosing.…”

Re‐evaluation of celluloses E 460(i), E 460(ii), E 461, E 462, E 463, E 464, E 465, E 466, E 468 and E 469 as food additives

“…The absorption and excretion of NaCMC was examined in rats (Bär et al., ). The 14 C label was in the two carbon atoms of the carboxymethyl group and the specific radioactivity was 0.27 μCi/mg.…”

“…As reported above, a comparative disposition study was carried out with 14 C‐labelled sodium CMC and enzymatically hydrolysed sodium CMC in adult Wistar rats (8 animals/sex; age not stated) (Bär et al., ). The enzymatically hydrolysed sodium CMC was recovered from the GI tract with an unchanged molecular weight, whereas the sodium CMC was reduced in molecular size.…”

“…The absorption and excretion of partially enzyme‐hydrolysed 14 C‐labelled enzymatically hydrolysed carboxy methyl cellulose was compared in rats to those of CMC in the above described study (Bär et al., ). Following the same experimental protocol, most of the radioactivity (89–99% of the dose) was excreted within 48 h after dosing.…”

The results of preventing postoperative achilles tendon adhesion using cross-linked and non-cross-linked hyaluronic acid, a study with rat model

“…The hyaluronate is a non-sulfated glycosaminoglycan, which is one of the chief components of the extracellular matrix [14]. The hyaluronate modulates cell proliferation and migration and prevents inflammation [15]. Based on this property of hyaluronate, it has been used as an antiadhesive agent in various surgeries, such as gynecological surgery, abdominal surgery, spine surgery, and tendon surgery, to prevent postoperative adhesion with promising results [16][17][18].…”

Dietary Emulsifier–Induced Low-Grade Inflammation Promotes Colon Carcinogenesis

“…These two emulsifiers are indigestible and mainly excreted in the feces (26–29), and we recently found that both CMC and P80 promoted microbiota encroachment and increased levels of pro-inflammatory flagellin and lipopolysaccharide (LPS), which correlated with a change in microbiota composition and intestinal inflammation. Such alterations promoted colitis in mice genetically predisposed to this disorder, and induced low-grade inflammation and metabolic syndrome in WT mice.…”

Re‐evaluation of celluloses E 460(i), E 460(ii), E 461, E 462, E 463, E 464, E 465, E 466, E 468 and E 469 as food additives

“…The absorption and excretion of NaCMC was examined in rats (Bär et al., ). The 14 C label was in the two carbon atoms of the carboxymethyl group and the specific radioactivity was 0.27 μCi/mg.…”

“…As reported above, a comparative disposition study was carried out with 14 C‐labelled sodium CMC and enzymatically hydrolysed sodium CMC in adult Wistar rats (8 animals/sex; age not stated) (Bär et al., ). The enzymatically hydrolysed sodium CMC was recovered from the GI tract with an unchanged molecular weight, whereas the sodium CMC was reduced in molecular size.…”

“…The absorption and excretion of partially enzyme‐hydrolysed 14 C‐labelled enzymatically hydrolysed carboxy methyl cellulose was compared in rats to those of CMC in the above described study (Bär et al., ). Following the same experimental protocol, most of the radioactivity (89–99% of the dose) was excreted within 48 h after dosing.…”

The results of preventing postoperative achilles tendon adhesion using cross-linked and non-cross-linked hyaluronic acid, a study with rat model

“…The hyaluronate is a non-sulfated glycosaminoglycan, which is one of the chief components of the extracellular matrix [14]. The hyaluronate modulates cell proliferation and migration and prevents inflammation [15]. Based on this property of hyaluronate, it has been used as an antiadhesive agent in various surgeries, such as gynecological surgery, abdominal surgery, spine surgery, and tendon surgery, to prevent postoperative adhesion with promising results [16][17][18].…”

Dietary Emulsifier–Induced Low-Grade Inflammation Promotes Colon Carcinogenesis

“…These two emulsifiers are indigestible and mainly excreted in the feces (26–29), and we recently found that both CMC and P80 promoted microbiota encroachment and increased levels of pro-inflammatory flagellin and lipopolysaccharide (LPS), which correlated with a change in microbiota composition and intestinal inflammation. Such alterations promoted colitis in mice genetically predisposed to this disorder, and induced low-grade inflammation and metabolic syndrome in WT mice.…”

Re‐evaluation of celluloses E 460(i), E 460(ii), E 461, E 462, E 463, E 464, E 465, E 466, E 468 and E 469 as food additives

“…The absorption and excretion of NaCMC was examined in rats (Bär et al., ). The 14 C label was in the two carbon atoms of the carboxymethyl group and the specific radioactivity was 0.27 μCi/mg.…”

“…As reported above, a comparative disposition study was carried out with 14 C‐labelled sodium CMC and enzymatically hydrolysed sodium CMC in adult Wistar rats (8 animals/sex; age not stated) (Bär et al., ). The enzymatically hydrolysed sodium CMC was recovered from the GI tract with an unchanged molecular weight, whereas the sodium CMC was reduced in molecular size.…”

“…The absorption and excretion of partially enzyme‐hydrolysed 14 C‐labelled enzymatically hydrolysed carboxy methyl cellulose was compared in rats to those of CMC in the above described study (Bär et al., ). Following the same experimental protocol, most of the radioactivity (89–99% of the dose) was excreted within 48 h after dosing.…”

The results of preventing postoperative achilles tendon adhesion using cross-linked and non-cross-linked hyaluronic acid, a study with rat model

“…The hyaluronate is a non-sulfated glycosaminoglycan, which is one of the chief components of the extracellular matrix [14]. The hyaluronate modulates cell proliferation and migration and prevents inflammation [15]. Based on this property of hyaluronate, it has been used as an antiadhesive agent in various surgeries, such as gynecological surgery, abdominal surgery, spine surgery, and tendon surgery, to prevent postoperative adhesion with promising results [16][17][18].…”

Dietary Emulsifier–Induced Low-Grade Inflammation Promotes Colon Carcinogenesis

“…These two emulsifiers are indigestible and mainly excreted in the feces (26–29), and we recently found that both CMC and P80 promoted microbiota encroachment and increased levels of pro-inflammatory flagellin and lipopolysaccharide (LPS), which correlated with a change in microbiota composition and intestinal inflammation. Such alterations promoted colitis in mice genetically predisposed to this disorder, and induced low-grade inflammation and metabolic syndrome in WT mice.…”