Metabolic changes in malnutrition

Emery, Peter W.

doi:10.1038/sj.eye.6701959

Cited by 73 publications

(49 citation statements)

References 22 publications

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“…The inadequate supply of nutrients causes changes in anthropometric, metabolic, as well as intestinal morphology of individuals 4,20 , decreasing the body's ability to combat pathogens 21 , as G. lamblia, worsening nutritional status, especially of children. However, the influence of nutritional deficit in the severity of giardiasis or by the infection on nutritional status of parasitized is still speculative 22 .…”

Section: Discussionmentioning

confidence: 99%

Changes in oxidative stress and lipoprotein in malnourished gerbils infected with Giardia lamblia

Ventura

Caliari

Santos³

et al. 2014

Free Rad. Antiox.

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Introduction:It is speculated that giardiasis, one of the most common parasites in the world, would produce metabolic changes that worsen the nutritional status of malnourished or immunocompromised patients. In this context, we seek to contribute to clarify this issue by evaluating the effects of infection on antioxidant defense and lipoprotein metabolism in gerbils previously malnourished. Methods: 32 gerbils were used, divided into four groups: Control (CT) and Control Infected (CTIn), which each received a 20% protein diet, Malnourished (MN) and Malnourished Infected (MNIn), which each received a 5% protein diet. CTIn and MNIn groups were inoculated with 1×10 6 trophozoites of G. lamblia, while the remaining groups were mock infected. Seven days post-infection, all groups were sacrificed and hepatic tissue collected for assessment of oxidative stress via dosing catalase and superoxide dismutase and serum was collected to evaluate the lipoprotein metabolism by Fast Protein Liquid Chromatography. In each fraction, cholesterol concentration was determined using commercial kits, and protein by absorbance difference. Results: Gerbils fed with a low protein diet had significantly lower body weight. Cholesterol and protein in the fractions were significantly lower in group MNIn compared to CT and Catalase activity was higher in group MNIn compared to control. Conclusions: Our results demonstrated that host response against giardiasis associated to malnutrition, led to an oxidative stress that produced changes on lipoprotein composition in the malnourished animals suggesting that the infection could influence on metabolic changes, worsening the nutritional status of infected animals.

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Section: Discussionmentioning

confidence: 99%

Changes in oxidative stress and lipoprotein in malnourished gerbils infected with Giardia lamblia

Ventura

Caliari

Santos³

et al. 2014

Free Rad. Antiox.

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“…Conseqüentemente, a utilização da glicose como substrato energético pelo sistema nervoso será diminuída gradativamente com a prolongação do tempo de desnutrição, de 80g/dia para cerca de 35/g/dia (EMERY, 2005), apresentando assim, uma importante vantagem ao desnutrido, já que menos glicose precisa ser obtida pela gliconeogênese a partir de amino ácidos do músculo esquelético, permitindo uma maior preservação desse tecido. Além dessa importante adaptação ao estresse da desnutrição, a cetose também promove um importante efeito poupador de glicose, que por sua vez, pode produzir um efeito poupador das reservas de glicogênio (SALWAY, 2004b).…”

Section: Discussionunclassified

Alterações metabólicas em ratos desnutridos em resposta ao treinamento de endurance.

Giampietro¹

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“…Nesta fase têm início as alterações no metabolismo de gordura e proteínas, que levam a uma rápida perda de peso e degradação progressiva dos estoques protéicos (EMERY, 2005). A degradação protéica tem como objetivo primário suprir o fígado de substratos neoglicogênicos, para manutenção da glicemia.…”

Section: A Desnutriçãounclassified

“…O alto custo energético do processo, no entanto, aumenta a necessidade de síntese de ATP a partir da oxidação de ácidos graxos, notadamente aqueles de cadeia longa, alimentando, positivamente, o ciclo de degradação de substratos e perda de massa. O catabolismo protéico leva a perda muscular, com comprometimento da função visceral e redução do consumo de O 2 (YOUNG e SCRIMSHAW, 1971, SHETTY, 1999CARBONNEL, 2000;EMERY, 2005).…”

Metabolic changes in malnutrition

Cited by 73 publications

References 22 publications

Changes in oxidative stress and lipoprotein in malnourished gerbils infected with Giardia lamblia

Changes in oxidative stress and lipoprotein in malnourished gerbils infected with Giardia lamblia

Alterações metabólicas em ratos desnutridos em resposta ao treinamento de endurance.

Influência do exercício sobre a resposta imunológica de ratos desnutridos.

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