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“…Later on, an inverse relationship was shown between meal frequency and BMI in some (39) but not all populations studied (5,18). Limited scientific literature on scheduled feeding, some going back more than 50 years, showed that force-fed rats also display a completely different metabolism with a concomitant change in body composition compared with freely fed rats despite similar caloric intake (2,4,10,11).…”
mentioning
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“…Later on, an inverse relationship was shown between meal frequency and BMI in some (39) but not all populations studied (5,18). Limited scientific literature on scheduled feeding, some going back more than 50 years, showed that force-fed rats also display a completely different metabolism with a concomitant change in body composition compared with freely fed rats despite similar caloric intake (2,4,10,11).…”
mentioning
“…Although it is widely accepted that MFS rats exhibit elevated hepatic glycogen levels during intermeal periods [3,5,13,25,27], to the authors' knowledge, this is the first investigation of the effect of feeding training on glycogen synthase. Additionally, MFS increased food ingestion from day 1 to day 13 of feeding training.…”
Section: Discussionmentioning
“…An increased hepatic capacity to store glycogen during the intermeal period can be observed during the first week [27], and this response is intensified when this feeding scheme is prolonged to 4 [13] or 20 [12] weeks. Furthermore, better maintenance of glycemia during fasting [2,4,5,13] has been found.…”
Section: Introductionmentioning
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“…In addition, delayed gastric emptying (128) and an increase in intestinal absorbing area due to mucosal hypertrophy have been observed (131). The periodicity of food presentation is an important factor for the establishment of the metabolic changes, since the same amount of food given randomly in time to food-restricted rats promotes a different adaptive metabolic pattern (132). Corticosteroids seem to be required for the metabolic adaptation since adrenalectomized animals do not survive food restriction due to lack of lipogenesis, gluconeogenesis and glucogenolysis (133) to efficiently supply energy in the intermeal period.…”
Section: Diurnal Rhythms Of the Hypothalamicpituitary-adrenal Axis Anmentioning