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Cited by 7 publications
(4 citation statements)
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References 6 publications
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“…A well-described example is the fruit fly, where inflammation-induced changes in intestinal homeostasis contribute to mortality as the animal ages. These age-related inflammatory alterations are also tightly correlated with systemic metabolic dysfunction 12 , and limiting inflammation is sufficient to extend lifespan 10 .…”
mentioning
confidence: 99%
“…A well-described example is the fruit fly, where inflammation-induced changes in intestinal homeostasis contribute to mortality as the animal ages. These age-related inflammatory alterations are also tightly correlated with systemic metabolic dysfunction 12 , and limiting inflammation is sufficient to extend lifespan 10 .…”
mentioning
confidence: 99%
“…It is now accepted that chronic inflammation is the main underlying condition in many diseases associated with aging such as atherosclerosis, osteoarthritis, cancer, diabetes, osteoporosis, dementia, vascular diseases, obesity and metabolic syndrome [30,31] (Table 2). In populations aged human metabolic dysfunction, particularly insulin resistance and inflammatory disorders are very common and identify the molecular mechanisms underlying the immune-metabolic integration becomes important for understanding the pathogenesis of these diseases and their approach therapeutic.…”
Section: Implications For Clinical Practicementioning
confidence: 99%
“…Another critical issue is that, in general, in vivo experiments are mainly performed with young or middle aged healthy rodents, thereby neglecting the impact of co-morbidities and the influence of aging in humans, which dramatically affect vaccine efficacy [128]. There is still a paucity of knowledge on the entity and exact causes of the functional alterations observed in the immune system of aging individuals.…”
Section: Expert Commentarymentioning
confidence: 99%