Metabolic activity of Bacillus coagulans R11 and the health benefits of and potential pathogen inhibition by this species in the intestines of laying hens under lead exposure

Xing, Si-Cheng; Mi, Jiandui; Chen, Jingyuan; Hu, Jiaxin; Liao, Xindi

doi:10.1016/j.scitotenv.2019.134507

Cited by 15 publications

(8 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the metagenomics results showed that B. coagulans R11 was found in only groups R11 and R11-Pb, which meant that B. coagulans R11 could tolerate the digestive juice of laying hens and possibly played a protection function. This result was the same as that of a previous study (Xing et al, 2020). The results showed that the concentration of α-solanine in the cecum increased obviously with B. coagulans R11 feeding.…”

Section: α-Solanine Was a Major Alkaloid Metabolite In The B Coagulasupporting

confidence: 90%

“…In addition, previous studies also found that B. coagulans R11 feeding, especially with regard to lead exposure, could decrease the abundance of potential pathogens (Xing et al, 2019b(Xing et al, , 2020. Although the metabonomics of the culture medium of B. coagulans R11 showed that some compounds were the major metabolites that were also antibiotic compounds, this result was not sufficient to assess the potential pathogen inhibition ability of B. coagulans R11 in the animal gut environment due to the more-complex substrates and the influences of the gut microbiome (Xing et al, 2020). Therefore, the reasons why B. coagulans R11 feeding, especially in lead-exposed animals, could inhibit the abundance of potential pathogens were investigated based on the real-world environment of the animal gut in this study.…”

Section: Introductionmentioning

confidence: 91%

“…In previous studies, B. coagulans R11 was used to feed mice and laying hens that were exposed to lead. Based on the lead adsorption capacity of B. coagulans R11, lead could be removed from manure to reduce the toxicity of lead on experimental animals (Xing et al, 2019b(Xing et al, , 2020. In addition, previous studies also found that B. coagulans R11 feeding, especially with regard to lead exposure, could decrease the abundance of potential pathogens (Xing et al, 2019b(Xing et al, , 2020.…”

Section: Introductionmentioning

confidence: 99%

“…Based on the lead adsorption capacity of B. coagulans R11, lead could be removed from manure to reduce the toxicity of lead on experimental animals (Xing et al, 2019b(Xing et al, , 2020. In addition, previous studies also found that B. coagulans R11 feeding, especially with regard to lead exposure, could decrease the abundance of potential pathogens (Xing et al, 2019b(Xing et al, , 2020. Although the metabonomics of the culture medium of B. coagulans R11 showed that some compounds were the major metabolites that were also antibiotic compounds, this result was not sufficient to assess the potential pathogen inhibition ability of B. coagulans R11 in the animal gut environment due to the more-complex substrates and the influences of the gut microbiome (Xing et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Combination of Lead and Bacillus coagulans R11 Increased the Concentration of Alpha-Solanine in the Cecum of Laying Hens and the Pathogens Abundance Decreased

Xing¹,

Chen²,

Chen³

et al. 2020

Front. Microbiol.

Self Cite

View full text Add to dashboard Cite

Alpha-solanine is an alkaloid that can inhibit the growth of pathogens and cancer cells, the present study proved that feeding with Bacillus coagulans R11 increases the concentration of alpha-solanine in the cecum of laying hens, which also decreases the abundance of potential pathogens. In addition, the bacteria genera, metabolism pathways and its proteins involved in the biosynthesis of alpha-solanine in the cecum were also characterized. The results showed that B. coagulans R11 feeding could increase the concentration of alpha-solanine, even with lead exposure. Mevalonic acid and MEP/DOXP pathways were both participated in the biosynthesis of alpha-solanine; at the same time, the gut metabolites (S)-2-amino-6-oxohexanoate, N2-succinyl-Lornithine and the bacteria proteins atoB, ispH were shown to be crucial role in the biosynthesis of alpha-solanine in the gut. The genera Faecalibacterium sp. An77 and Faecalibacterium sp. An58 2 were important in the biosynthesis of alpha-solanine, which provided the key proteins atoB and ispH. In addition, alpha-solanine could decrease the abundance of Prevotella sp. 109 and Prevotella marshii. In conclusion, alpha-solanine could be biosynthesized by cecal microorganisms with the stimulation of B. coagulans R11 in the intestine of laying hens, in addition, alpha-solanine was the main compound which also decreased the abundance of gut potential.

show abstract

Section: α-Solanine Was a Major Alkaloid Metabolite In The B Coagulasupporting

confidence: 90%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Combination of Lead and Bacillus coagulans R11 Increased the Concentration of Alpha-Solanine in the Cecum of Laying Hens and the Pathogens Abundance Decreased

Xing¹,

Chen²,

Chen³

et al. 2020

Front. Microbiol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…2020; Xing et al . 2020). The most common probiotic bacteria belong to the lactic acid bacteria (LAB) group or Bacillus genus (Maldonado‐Galdeano et al .…”

Section: Introductionmentioning

confidence: 99%

Probiotic supplementation containing Bacillus velezensis enhances expression of immune regulatory genes against pigeon circovirus in pigeons ( Columba livia )

Tsai

Santos

et al. 2020

J Appl Microbiol

View full text Add to dashboard Cite

Aims In this study, we aimed to isolate and evaluate the efficacy of Bacillus velezensis as a probiotic and to assess its activity towards pigeons infected with pigeon circovirus (PiCV). Methods and Results Bacillus velezensis, isolated from pigeon faeces, was orally administered to pigeons for 60 days. After pigeons were challenged with PiCV, the PiCV viral load and expression of indicator genes for innate immunity were detected in spleen tissue and faeces of pigeons. Bacillus velezensis significantly reduced the PiCV viral load in the faeces and spleen of pigeons 5 days post‐challenge (dpc). The mRNA expression levels of treated pigeons showed that interferon‐gamma (IFN‐γ), myxovirus resistance 1 (Mx1), and signal transducers and activators of transcription 1 (STAT1) genes were upregulated, whereas no expression of interleukin‐4 (IL‐4) was detected. Moreover, toll‐like receptor 2 (TLR2) and 4 (TLR4) were significantly upregulated in probiotic‐treated pigeons (P < 0·05). Conclusions This is the first report showing that probiotic supplementation can effectively enhance the T‐helper type 1 immune response and decrease the PiCV viral loads in pigeons. Significance and Impact of the Study This study proposes that the administration of a probiotic strain, B. velezensis, to pigeons can protect against PiCV infection.

show abstract

Nanosensors for animal health monitoring

Younis

Zia

Tahir

et al. 2022

Nanosensors for Smart Agriculture

View full text Add to dashboard Cite

Metabolic activity of Bacillus coagulans R11 and the health benefits of and potential pathogen inhibition by this species in the intestines of laying hens under lead exposure

Cited by 15 publications

References 60 publications

The Combination of Lead and Bacillus coagulans R11 Increased the Concentration of Alpha-Solanine in the Cecum of Laying Hens and the Pathogens Abundance Decreased

The Combination of Lead and Bacillus coagulans R11 Increased the Concentration of Alpha-Solanine in the Cecum of Laying Hens and the Pathogens Abundance Decreased

Probiotic supplementation containing Bacillus velezensis enhances expression of immune regulatory genes against pigeon circovirus in pigeons ( Columba livia )

Nanosensors for animal health monitoring

Contact Info

Product

Resources

About