Meta-analytical Comparison of Voxel-Based Morphometry Studies in Obsessive-Compulsive Disorder vs Other Anxiety Disorders

Abstract

The meta-analysis consistently revealed common as well as distinct neural substrates in OCD and other anxiety disorders. These results have implications for the current debate surrounding the classification of OCD in the DSM-V.

Cortical thickness in obsessive–compulsive disorder: Multisite mega-analysis of 780 brain scans from six centres

“…Although previous VBM studies have found greater striatal volume, 4,7 the same findings could not be replicated in this mega-analysis. A possible reason for the absence of this finding is as a result of the manner in which Freesurfer segments subcortical structures.…”

“…Both our data and previous work suggest at least some involvement of parietal and temporal regions in OCD, 4,7,11 consistent with the suggested involvement of the fronto-parietal and limbic circuits in the pathophysiology of OCD. The results also held true after exclusion of patients on medication and with lifetime comorbid anxiety and/or depression.…”

Cortical thickness in obsessive–compulsive disorder: Multisite mega-analysis of 780 brain scans from six centres

“…Although previous VBM studies have found greater striatal volume, 4,7 the same findings could not be replicated in this mega-analysis. A possible reason for the absence of this finding is as a result of the manner in which Freesurfer segments subcortical structures.…”

“…Both our data and previous work suggest at least some involvement of parietal and temporal regions in OCD, 4,7,11 consistent with the suggested involvement of the fronto-parietal and limbic circuits in the pathophysiology of OCD. The results also held true after exclusion of patients on medication and with lifetime comorbid anxiety and/or depression.…”

Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder

“…The basal ganglia have long been considered mediators of OCD symptoms [ 43 ], and many neuroimaging studies have shown OCD-associated increases in the GM volume and metabolism/activation of the striatum [ 29 , 44–49 ]. Consistent with human findings [ 45 , 50 ], we found that SMB monkeys had larger caudate nuclei than control monkeys. Notably, caudate nucleus GM volume correlated positively with daily duration of monkey SMBs.…”

Behavioral Problems in Offspring of Bipolar Mothers

“…Another results in other studies (21,18,13,(4)(5)(6) were assessed, which were similar to the result of current study. Internalization and externalization scale's results in former studies (47)(48)(49) are consistent with the result of current study.…”

Cortical thickness in obsessive–compulsive disorder: Multisite mega-analysis of 780 brain scans from six centres

“…Although previous VBM studies have found greater striatal volume, 4,7 the same findings could not be replicated in this mega-analysis. A possible reason for the absence of this finding is as a result of the manner in which Freesurfer segments subcortical structures.…”

“…Both our data and previous work suggest at least some involvement of parietal and temporal regions in OCD, 4,7,11 consistent with the suggested involvement of the fronto-parietal and limbic circuits in the pathophysiology of OCD. The results also held true after exclusion of patients on medication and with lifetime comorbid anxiety and/or depression.…”

Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder

“…The basal ganglia have long been considered mediators of OCD symptoms [ 43 ], and many neuroimaging studies have shown OCD-associated increases in the GM volume and metabolism/activation of the striatum [ 29 , 44–49 ]. Consistent with human findings [ 45 , 50 ], we found that SMB monkeys had larger caudate nuclei than control monkeys. Notably, caudate nucleus GM volume correlated positively with daily duration of monkey SMBs.…”

Behavioral Problems in Offspring of Bipolar Mothers

“…Another results in other studies (21,18,13,(4)(5)(6) were assessed, which were similar to the result of current study. Internalization and externalization scale's results in former studies (47)(48)(49) are consistent with the result of current study.…”

Cortical thickness in obsessive–compulsive disorder: Multisite mega-analysis of 780 brain scans from six centres

“…Although previous VBM studies have found greater striatal volume, 4,7 the same findings could not be replicated in this mega-analysis. A possible reason for the absence of this finding is as a result of the manner in which Freesurfer segments subcortical structures.…”

“…Both our data and previous work suggest at least some involvement of parietal and temporal regions in OCD, 4,7,11 consistent with the suggested involvement of the fronto-parietal and limbic circuits in the pathophysiology of OCD. The results also held true after exclusion of patients on medication and with lifetime comorbid anxiety and/or depression.…”

Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder

“…The basal ganglia have long been considered mediators of OCD symptoms [ 43 ], and many neuroimaging studies have shown OCD-associated increases in the GM volume and metabolism/activation of the striatum [ 29 , 44–49 ]. Consistent with human findings [ 45 , 50 ], we found that SMB monkeys had larger caudate nuclei than control monkeys. Notably, caudate nucleus GM volume correlated positively with daily duration of monkey SMBs.…”

Behavioral Problems in Offspring of Bipolar Mothers

“…Another results in other studies (21,18,13,(4)(5)(6) were assessed, which were similar to the result of current study. Internalization and externalization scale's results in former studies (47)(48)(49) are consistent with the result of current study.…”